PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma

Conclusion: Our results demonstrate 131I-PARPi’s high potential as a therapeutic and highlight PARP’s relevance as a target for radionuclide therapy. Radiation plays an integral role in brain tumor therapy, and radiolabeled PARP therapeutics could ultimately lead to improvements in the standard of care.

Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Jannetti, S. A., Carlucci, G., Carney, B., Kossatz, S., Shenker, L., Carter, L. M., Salinas, B., Brand, C., Sadique, A., Donabedian, P. L., Cunanan, K. M., Gonen, M., Ponomarev, V., Zeglis, B. M., Souweidane, M. M., Lewis, J. S., Weber, W. A., Humm, J. L. Tags: Basic Source Type: research