How are Malformations of the Cerebral Cortex Grouped?

Discussion Cerebral cortex development is an extremely complex process overall. Our current understanding is incomplete and constantly changing as our understanding of genetics and the processes each gene controls emerges from scientific research. Neural cells are produced in the subventicular zone of the pallial or dorsal germinal epithelium. They then differentiate and migrate radially or tangentially to the cerebral cortex and organize themselves to function. Malformations of cortical development (MCD) is a heterogeneneous group of disorders that cause defective cortical development. These disorders are broadly categorized into three areas of cerebral cortical development: neural cell proliferation, neural cell migration and cortical organization. There is wide variation in the radiographic features and clinical problems seen and individuals may have more than one of these broad classifications (i.e. have elements 1 or all 3 classifications such as polymicrogyri). Additionally, the brain may be affected with these malformations globally or focally (focal cortical development). Specific wording and classifications for MCDs are necessarily changing as more information is learned. Malformations of cortical development presenting signs and prognosis predictors are shown in this table, modified from Guerrini and Dobyns (see To Learn More below). MCDs that are more global or that are due to neural cell proliferation problems are often more severe. Characteristic Most Seve...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Publication date: Available online 6 April 2020Source: Epilepsy &BehaviorAuthor(s): Fabio Minicucci, Monica Ferlisi, Francesco Brigo, Oriano Mecarelli, Stefano Meletti, Umberto Aguglia, Roberto Michelucci, Massimo Mastrangelo, Nicola Specchio, Stefano Sartori, Paolo Tinuper
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Ischemic stroke damages the blood-brain barrier (BBB), which leads to brain edema and increases the risk of intracranial hemorrhage. Proteasome inhibition has been found to protect the BBB against cerebral ischemia by suppressing neuroinflammation-mediated matrix metalloproteases-9 (MMP-9) activation. We recently showed that ginsenoside Rd (Rd), a major active ingredient of Panax ginseng, could suppress proteasome-mediated inflammation and be efficient for treating ischemic stroke but downstream mechanisms were still unidentified. For this purpose, Sprague–Dawley rats were subjected to focal cerebral ischemic injury....
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
AbstractThe utility of abdominal aortic calcification (AAC) for prediction of cardiovascular events (CVEs) in patients with acute coronary syndrome (ACS) remains to be determined. The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a semi-quantitative measure of AAC, for CVEs in patients with ACS. We evaluated 314 patients with ACS. All patients underwent successful percutaneous coronary intervention to the culprit coronary vessel without in-hospital adverse events. ACI was calculated on non-contrast computed tomography images. CVEs were defined as a co...
Source: Heart and Vessels - Category: Cardiology Source Type: research
Condition:   Stroke Interventions:   Device: Robotic group (Upper extremity robot-assisted training plus routine physical and rehabilitation medicine program);   Behavioral: Control group (routine physical and rehabilitation medicine program) Sponsor:   Ankara University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A friend of mine takes a statin medication each day to lower his cholesterol. More than once I’ve heard him say “I ate too much! I’m going to have to take an extra pill.” Never mind that it doesn’t work that way — a single additional statin pill won’t make much difference to his cholesterol or his health. And never mind that you shouldn’t self-adjust the dose of your medications (talk to your doctor before making any changes in medication dosing). But my friend’s overindulging does bring up the question of whether starting medications for conditions like high blood pres...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Exercise and Fitness Health Healthy Eating Heart Health Hypertension and Stroke Source Type: blogs
Just how well does radiography perform in detecting signs of COVID‑19?...Read more on AuntMinnie.comRelated Reading: Open-source AI COVID-Net targets COVID-19 on chest x-rays Imaging confirms coronavirus transmits from mother to fetus Radiology has key role to play in the midst of COVID-19 X-ray may be missing COVID-19 cases found with CT X-ray, CT uncover novel coronavirus-infected pneumoniaComments: 4/6/2020 11:13:10 AMFabio R Very interesting the article, I wonder if in an ICU or in a triage a digital mobile x-ray with a maximum of 250 mAs is sufficient, instead favoring the weight and size of a smaller ge...
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Virginia Tech) Unprovoked recurrent seizures are a serious problem affecting most patients who suffer from glioma, a primary brain tumor composed of malignant glial cells. Fralin Biomedical Research Institute researchers tested the hypothesis that glioma-induces processes that renders a type of brain cells dysfunctional, perpetuating the imbalance between excitation and inhibition in tumor-associated epilepsy.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Discussion The embryonic mesoderm forms the skeletal system. The mesoderm is further divided into the dorsal, sclerotome and ventral dermatome. The sclerotome forms the ribs which are under the influence of various genes and growth factors. Congenital rib abnormalities occur in number ( the normal 12 ribs) or in formation/structural. Malformations can include hypoplastic, bridging, forked, fused and hypoplastic ribs. Even ribs with holes occur because of the segmentation issues. Illustrated examples can be found here. The rib’s cartilage, bone or both can be affected. Location along the rib is also variable. Abnormal...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
UK experts are concerned that people are not seeking urgent NHS help when they need it.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
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