Janssen Announces Health Canada Approval of CABENUVA ™, the First Long-Acting Regimen for the Treatment of HIV
Cork, Ireland, March 20, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that Health Canada has approved CABENUVA™ (cabotegravir and rilpivirine extended release injectable suspensions), the first and only once-monthly, long-acting regimen for the treatment of HIV-1 infection in adults. CABENUVA™ is indicated as a complete regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in patients who are virologically stable and suppressed (HIV-1 RNA less than 50 copies per milliliter [mL]). CABENUVA™, a co-packaged kit with ...
Source: Johnson and Johnson - March 20, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Highlights Continued Commitment to Cardiovascular & Metabolic Healthcare Solutions with Late-Breaking Data at the First Fully Virtual American College of Cardiology Scientific Session
RARITAN, N.J., March 20, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that it will unveil late-breaking data from its leading cardiovascular and metabolism portfolio during the virtual American College of Cardiology’s 69th Annual Scientific Session together with the World Congress of Cardiology (ACC.20/WCC) on March 28-30, 2020. Notably, four late-breaking abstracts for XARELTO® (rivaroxaban) will be presented, including data from the Phase 3 VOYAGER PAD study in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization.Click to...
Source: Johnson and Johnson - March 20, 2020 Category: Pharmaceuticals Source Type: news

Taro Pharmaceuticals U.S.A. Issues Voluntary Nationwide Recall of Phenytoin Oral Suspension Usp, 125 Mg/5 Ml due to Possible Underdosing or Overdosing
Taro Pharmaceuticals U.S.A., Inc. ( “Taro” or the “Company”) is voluntarily recalling two (2) lots of Phenytoin Oral Suspension USP, 125 mg/5 mL both in 237 mL bottles, to the consumer level. Phenytoin Oral Suspension USP, 125 mg/5 mL is indicated for the treatment of tonic-clonic (grand mal) and psy (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 5, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Supply Disruption Alert - Epanutin ® (phenytoin) 30mg/5ml Oral Suspension
The Department of Health and Social Care (DHSC) have issued a Supply Disruption Alert for... Epanutin® (phenytoin) 30mg/5ml oral suspension, which will be out of stock from w/c 2nd March until lat (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 27, 2020 Category: Drugs & Pharmacology Source Type: news

Taro Pharmaceuticals U.S.A. Issues Voluntary Nationwide Recall of Phenytoin Oral Suspension USP, 125 mg/5ml Due to Possible Underdosing or Overdosing
Taro Pharmaceuticals U.S.A., Inc. ( “Taro” or the “Company”) is voluntarily recalling two (2) lots of Phenytoin Oral Suspension USP, 125 mg/5 mL both in 237 mL bottles, to the consumer level. Phenytoin Oral Suspension USP, 125 mg/5 mL is indicated for the treatment of tonic-clonic (grand mal) and psy (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 21, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Supply Disruption Alert - Phenytoin Sodium NRIM 100mg capsules (Accord)
Accord will be.... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - January 10, 2020 Category: Drugs & Pharmacology Source Type: news

Man, 60, is left with HYPOTHERMIA 'because of his epilepsy medication'
Doctors in Glasgow tried to understand why the unnamed man had hypothermia because he had not been in the cold. 'Dangerously high' levels of medication phenytoin were found in his blood. (Source: the Mail online | Health)
Source: the Mail online | Health - June 7, 2019 Category: Consumer Health News Source Type: news

Epanutin (phenytoin) 30mg/5ml oral suspension supply disruption
The Department of Health and Social Care (DHSC) has advised that Pfizer expect that Epanutin (phenytoin) 30mg/5ml oral suspension will be out of stock from w/c 10th June for 6-8 weeks. (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - June 7, 2019 Category: Drugs & Pharmacology Source Type: news

Phenytoin not cost  effective for status epilepticus
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 31, 2019 Category: Drugs & Pharmacology Source Type: news

No Edge for Levetiracetam Over Phenytoin for Status Epilepticus No Edge for Levetiracetam Over Phenytoin for Status Epilepticus
Both levetiracetam and phenytoin are reasonable second-line treatment options for pediatric status epilepticus, new research shows.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 3, 2019 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Phenytek Extended Release Capsule (Phenytoin Sodium) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 30, 2019 Category: Drugs & Pharmacology Source Type: news

Sudan: Life-Saving Medicines in Short Supply in Sudan
[Radio Dabanga] Khartoum -The Sudan pharmaceutical sector reports a severe scarcity of asthma and allergy medicines, especially anti-seizure medication phenytoin, which costs SDG 1,000 ($20*) for 2mg, as well as a lack of life-saving immunoglobulin where the cost of one injection exceeds SDG 1,700 (*$36). (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 22, 2018 Category: African Health Source Type: news

Epanutin (phenytoin) 30mg/5ml oral suspension -supply disruption
The Department of Health& Social Care (DHSC) has issued a supply disruption alert for Epanutin (phenytoin) 30mg/5ml oral suspension. (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 23, 2018 Category: Drugs & Pharmacology Source Type: news

Phenytoin Sodium Injection, USP (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - August 2, 2018 Category: Drugs & Pharmacology Source Type: news

How are Malformations of the Cerebral Cortex Grouped?
Discussion Cerebral cortex development is an extremely complex process overall. Our current understanding is incomplete and constantly changing as our understanding of genetics and the processes each gene controls emerges from scientific research. Neural cells are produced in the subventicular zone of the pallial or dorsal germinal epithelium. They then differentiate and migrate radially or tangentially to the cerebral cortex and organize themselves to function. Malformations of cortical development (MCD) is a heterogeneneous group of disorders that cause defective cortical development. These disorders are broadly catego...
Source: PediatricEducation.org - July 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Company led recall - Unlicensed Medicine Phenytoin 90mg/5ml Oral Suspension
The Medicines and Healthcare Products Regulatory Agency (MHRA) have issued a company led recall for specific batches of unlicensed medicine Phenytoin 90mg/5ml Oral Suspension (Rosemont Pharmaceuticals (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - May 17, 2018 Category: Drugs & Pharmacology Source Type: news

Phenytoin Sodium Injection, USP (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 23, 2018 Category: Drugs & Pharmacology Source Type: news

Dilantin (Phenytoin) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 4, 2017 Category: Drugs & Pharmacology Source Type: news

NOAC-Drug Interactions Linked to Increased Bleeding NOAC-Drug Interactions Linked to Increased Bleeding
Concurrent use of amiodarone, fluconazole, rifampin, and phenytoin was associated with increased risk for major bleeding compared with the use of NOACs alone in a new study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 6, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Pfizer appeals $107m fine for anti-epilepsy drug prices in UK
Pfizer (NYSE:PFE) and Flynn Pharma have appealed the record $107 million (£84.2 million) and $6.5 million (£5.2 million) fines imposed by the U.K. Competition & Markets Authority in December for the companies’ massive price hikes to their unbranded versions of anti-epilepsy drug Epanutin. In its appeal, Pfizer claims that the regulator did not consider market realities when it fined the drugmaker, saying “Pfizer challenges the CMA’s conclusion that it was dominant within the relevant market: the market for the manufacture of Pfizer-manufactured phenytoin sodium capsules that are ...
Source: Mass Device - February 15, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Legal News Pharmaceuticals Wall Street Beat Flynn Pharma Pfizer Source Type: news

A Quick Guide to Getting Enough Vitamin D
Shanna R. Levine, MD Instructor of General Internal Medicine The Mount Sinai Hospital A Quick Guide to Getting Enough Vitamin D If you are like many of my patients, you may be wondering, "Am I getting enough vitamin D?" This is a valid concern, because vitamin D plays a very important role in overall health and, in fact, many people do not get enough. The Centers for Disease Control and Prevention estimates that about one-third of Americans have insufficient levels. The good news is that sources of this vitamin are easily accessible. Why Is Vitamin D Important? Vitamin D helps the body absorb calcium from the...
Source: Healthy Living - The Huffington Post - January 30, 2017 Category: Consumer Health News Source Type: news

UK slaps Pfizer with record $107m fine over price hikes
The Competition and Markets Authority reportedly fined Pfizer (NYSE:PFE) and Flynn Pharma a record amount for the companies’ massive price hikes to its unbranded versions of the anti-epilepsy drug, Epanutin.  The British competition watchdog fined Pfizer and Flynn Pharma $107 million (£84.2 million) and $6.5 million (£5.2 million), respectively. New York City-based Pfizer used to market the anti-epilepsy treatment as the branded drug Epanutin. The company sold the rights to Flynn in September 2012 and Flynn debranded the drug, removing it from the scrutiny of price regulation, and hike...
Source: Mass Device - December 7, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Drug-Device Combinations Healthcare Reform Pharmaceuticals Regulatory/Compliance Wall Street Beat Flynn Pharma GlaxoSmithKline plc Pfizer Inc. Source Type: news

Phenytek Extended Release Capsule (Phenytoin Sodium) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 7, 2016 Category: Drugs & Pharmacology Source Type: news

UK's CMA fines Pfizer and Flynn Pharma nearly £ 90m for unfair pricing of epilepsy drug
Pfizer and Flynn Pharma have been fined nearly £ 90m by the Competition and Markets Authority (CMA) for charging unfair prices in the UK for phenytoin sodium capsules, an anti-epilepsy drug. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - December 7, 2016 Category: Pharmaceuticals Source Type: news

Dilantin Infatabs (Phenytoin Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Dilantin Kapseals (Extended Phenytoin Sodium Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Safety warning over incorrect use of injectable phenytoin
Clinicians have been warned about the risk of death and severe harm arising from the incorrect use of injectable phenytoin. (Source: Nursing Times)
Source: Nursing Times - November 9, 2016 Category: Nursing Source Type: news

phenytoin, Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Infatabs
Title: phenytoin, Dilantin, Dilantin Infatabs, Phenytek, Phenytoin InfatabsCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 11/3/2016 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - November 3, 2016 Category: Drugs & Pharmacology Source Type: news

Human exposures to pentobarbital-phenytoin combination veterinary drugs - Forrester MB.
A combination of pentobarbital and phenytoin is used as a veterinary euthanasia drug. Because of its lethal effect, this study described pentobarbital-phenytoin combination veterinary drug human exposures reported to Texas poison centers during 2000-2015. ... (Source: SafetyLit)
Source: SafetyLit - September 12, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Dilantin 125 (Phenytoin Oral Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 6, 2016 Category: Drugs & Pharmacology Source Type: news

New Evidence Backs Levetiracetam for Prolonged SeizureNew Evidence Backs Levetiracetam for Prolonged Seizure
Levetiracetam is as good as phenytoin for the treatment of status epilepticus, new data suggest, and might even be cheaper. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 25, 2016 Category: Consumer Health News Tags: Emergency Medicine News Source Type: news

Medical News Today: Nerve damage in MS could be prevented with epilepsy drug
An epilepsy drug - phenytoin - reduced nerve damage by 30% in people with optic neuritis, a new study found, bringing us closer to a neuroprotective drug for multiple sclerosis. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 26, 2016 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Cheap epilepsy drug could prevent nerve damage in Multiple Sclerosis
The anti-seizure drug phenytoin was found to protect neural tissue in MS patients with optic neuritis, potentially preventing the onset of blindess (Source: Telegraph Health)
Source: Telegraph Health - January 26, 2016 Category: Consumer Health News Tags: drug cure treatment help multiple sclerosis epilepsy therapy Source Type: news

Definitive paper on phenytoin/phosphenytoin-associated purple glove syndrome
Purple glove syndrome (fda.gov) 4.5 out of 5 stars Purple Glove Syndrome after Phenytoin or Fosphenytoin Administration: Review of Reported Cases and Recommendations for Prevention. Garbovsky LA et al. J Med Toxicol 2015 Dec;11:445-459. Abstract Purple glove syndrome (PGS) is an uncommon adverse drug reaction to parenteral administration of phenytoin or fosphenytoin marked by severe progressive soft tissue discoloration, swelling and pain in the distal extremity into which the drug was infused. This extremely well done and comprehensive paper will tell you all you need to know (well, probably more than you need t...
Source: The Poison Review - January 22, 2016 Category: Toxicology Authors: Leon Tags: Medical adverse drug reaction dilantin phenytoin phosphenytoin purple glove syndrome soft tissue Source Type: news

CMA accuses Pfizer and Flynn Pharma of overpricing anti-epilepsy drug
The UK’s Competition and Markets Authority (CMA) has accused US pharmaceutical giant Pfizer and drug firm Flynn Pharma of overpricing an anti-epilepsy drug, phenytoin sodium capsules. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - August 10, 2015 Category: Pharmaceuticals Source Type: news

NHS may have been overcharged 'millions' for common drug by Pfizer and Flynn Pharma
The Competition and Markets Authority is investigating whether Pfizer and Flynn Pharma used their position to charge ‘excessive and unfair’ prices for phenytoin sodium capsules. (Source: the Mail online | Health)
Source: the Mail online | Health - August 6, 2015 Category: Consumer Health News Source Type: news

Caustic injury and stricture of the esophagus after long-term phenytoin use - Nelson KK, Clayton SB, Champeaux AL, Feldman JC, Richter JE.
A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 15, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Aurobindo Pharma gets USFDA final nod for generic anti-epileptic drug
Aurobindo Pharma has received final nod from the US health regulator to make and market generic anti-epileptic Phenytoin Sodium capsules in America. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 15, 2015 Category: Pharmaceuticals Source Type: news

Anti-LINGO-1, biotin and phenytoin results reported at AAN 2015
(Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - May 5, 2015 Category: Neurology Source Type: news

Phenytoin Neuroprotective in MS Phenytoin Neuroprotective in MS
New data showing an epilepsy drug can protect against retinal nerve cell degeneration in optic neuritis is 'the most convincing demonstration of neuroprotection for MS to date,' researchers say. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 20, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news