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Pfizer appeals $107m fine for anti-epilepsy drug prices in UK
Pfizer (NYSE:PFE) and Flynn Pharma have appealed the record $107 million (£84.2 million) and $6.5 million (£5.2 million) fines imposed by the U.K. Competition & Markets Authority in December for the companies’ massive price hikes to their unbranded versions of anti-epilepsy drug Epanutin. In its appeal, Pfizer claims that the regulator did not consider market realities when it fined the drugmaker, saying “Pfizer challenges the CMA’s conclusion that it was dominant within the relevant market: the market for the manufacture of Pfizer-manufactured phenytoin sodium capsules that are ...
Source: Mass Device - February 15, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Legal News Pharmaceuticals Wall Street Beat Flynn Pharma Pfizer Source Type: news

A Quick Guide to Getting Enough Vitamin D
Shanna R. Levine, MD Instructor of General Internal Medicine The Mount Sinai Hospital A Quick Guide to Getting Enough Vitamin D If you are like many of my patients, you may be wondering, "Am I getting enough vitamin D?" This is a valid concern, because vitamin D plays a very important role in overall health and, in fact, many people do not get enough. The Centers for Disease Control and Prevention estimates that about one-third of Americans have insufficient levels. The good news is that sources of this vitamin are easily accessible. Why Is Vitamin D Important? Vitamin D helps the body absorb calcium from the...
Source: Healthy Living - The Huffington Post - January 30, 2017 Category: Consumer Health News Source Type: news

UK slaps Pfizer with record $107m fine over price hikes
The Competition and Markets Authority reportedly fined Pfizer (NYSE:PFE) and Flynn Pharma a record amount for the companies’ massive price hikes to its unbranded versions of the anti-epilepsy drug, Epanutin.  The British competition watchdog fined Pfizer and Flynn Pharma $107 million (£84.2 million) and $6.5 million (£5.2 million), respectively. New York City-based Pfizer used to market the anti-epilepsy treatment as the branded drug Epanutin. The company sold the rights to Flynn in September 2012 and Flynn debranded the drug, removing it from the scrutiny of price regulation, and hike...
Source: Mass Device - December 7, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Drug-Device Combinations Healthcare Reform Pharmaceuticals Regulatory/Compliance Wall Street Beat Flynn Pharma GlaxoSmithKline plc Pfizer Inc. Source Type: news

Phenytek Extended Release Capsule (Phenytoin Sodium) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 7, 2016 Category: Drugs & Pharmacology Source Type: news

UK's CMA fines Pfizer and Flynn Pharma nearly £ 90m for unfair pricing of epilepsy drug
Pfizer and Flynn Pharma have been fined nearly £ 90m by the Competition and Markets Authority (CMA) for charging unfair prices in the UK for phenytoin sodium capsules, an anti-epilepsy drug. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - December 7, 2016 Category: Pharmaceuticals Source Type: news

Dilantin Infatabs (Phenytoin Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Dilantin Kapseals (Extended Phenytoin Sodium Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Safety warning over incorrect use of injectable phenytoin
Clinicians have been warned about the risk of death and severe harm arising from the incorrect use of injectable phenytoin. (Source: Nursing Times)
Source: Nursing Times - November 9, 2016 Category: Nursing Source Type: news

phenytoin, Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Infatabs
Title: phenytoin, Dilantin, Dilantin Infatabs, Phenytek, Phenytoin InfatabsCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 11/3/2016 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - November 3, 2016 Category: Drugs & Pharmacology Source Type: news

Human exposures to pentobarbital-phenytoin combination veterinary drugs - Forrester MB.
A combination of pentobarbital and phenytoin is used as a veterinary euthanasia drug. Because of its lethal effect, this study described pentobarbital-phenytoin combination veterinary drug human exposures reported to Texas poison centers during 2000-2015. ... (Source: SafetyLit)
Source: SafetyLit - September 12, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Dilantin 125 (Phenytoin Oral Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 6, 2016 Category: Drugs & Pharmacology Source Type: news

New Evidence Backs Levetiracetam for Prolonged SeizureNew Evidence Backs Levetiracetam for Prolonged Seizure
Levetiracetam is as good as phenytoin for the treatment of status epilepticus, new data suggest, and might even be cheaper. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 25, 2016 Category: Consumer Health News Tags: Emergency Medicine News Source Type: news

Medical News Today: Nerve damage in MS could be prevented with epilepsy drug
An epilepsy drug - phenytoin - reduced nerve damage by 30% in people with optic neuritis, a new study found, bringing us closer to a neuroprotective drug for multiple sclerosis. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 26, 2016 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Cheap epilepsy drug could prevent nerve damage in Multiple Sclerosis
The anti-seizure drug phenytoin was found to protect neural tissue in MS patients with optic neuritis, potentially preventing the onset of blindess (Source: Telegraph Health)
Source: Telegraph Health - January 25, 2016 Category: Consumer Health News Tags: drug cure treatment help multiple sclerosis epilepsy therapy Source Type: news

Definitive paper on phenytoin/phosphenytoin-associated purple glove syndrome
Purple glove syndrome (fda.gov) 4.5 out of 5 stars Purple Glove Syndrome after Phenytoin or Fosphenytoin Administration: Review of Reported Cases and Recommendations for Prevention. Garbovsky LA et al. J Med Toxicol 2015 Dec;11:445-459. Abstract Purple glove syndrome (PGS) is an uncommon adverse drug reaction to parenteral administration of phenytoin or fosphenytoin marked by severe progressive soft tissue discoloration, swelling and pain in the distal extremity into which the drug was infused. This extremely well done and comprehensive paper will tell you all you need to know (well, probably more than you need t...
Source: The Poison Review - January 22, 2016 Category: Toxicology Authors: Leon Tags: Medical adverse drug reaction dilantin phenytoin phosphenytoin purple glove syndrome soft tissue Source Type: news

CMA accuses Pfizer and Flynn Pharma of overpricing anti-epilepsy drug
The UK’s Competition and Markets Authority (CMA) has accused US pharmaceutical giant Pfizer and drug firm Flynn Pharma of overpricing an anti-epilepsy drug, phenytoin sodium capsules. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - August 9, 2015 Category: Pharmaceuticals Source Type: news

NHS may have been overcharged 'millions' for common drug by Pfizer and Flynn Pharma
The Competition and Markets Authority is investigating whether Pfizer and Flynn Pharma used their position to charge ‘excessive and unfair’ prices for phenytoin sodium capsules. (Source: the Mail online | Health)
Source: the Mail online | Health - August 6, 2015 Category: Consumer Health News Source Type: news

Caustic injury and stricture of the esophagus after long-term phenytoin use - Nelson KK, Clayton SB, Champeaux AL, Feldman JC, Richter JE.
A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 15, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Aurobindo Pharma gets USFDA final nod for generic anti-epileptic drug
Aurobindo Pharma has received final nod from the US health regulator to make and market generic anti-epileptic Phenytoin Sodium capsules in America. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 15, 2015 Category: Pharmaceuticals Source Type: news

Anti-LINGO-1, biotin and phenytoin results reported at AAN 2015
(Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - May 4, 2015 Category: Neurology Source Type: news

Phenytoin Neuroprotective in MS Phenytoin Neuroprotective in MS
New data showing an epilepsy drug can protect against retinal nerve cell degeneration in optic neuritis is 'the most convincing demonstration of neuroprotection for MS to date,' researchers say. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 20, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Seizure Drug May Help in MS Eye Disease
(MedPage Today) -- Phenytoin shows promise for slowing neurodegeneration in optic neuritis. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - April 17, 2015 Category: Journals (General) Source Type: news

Phenytoin has neuroprotective effect suggests study
Research suggests that phenytoin, a drug used to treat seizures, may protect nerves from MS. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - April 16, 2015 Category: Neurology Source Type: news

The Treatment of Autism With Low-Dose PhenytoinThe Treatment of Autism With Low-Dose Phenytoin
Could a low dose of phenytoin, a widely used and well tolerated anti-epileptic medication, be effective in modifying the cognitive deficits associated with autism spectrum disorders? Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2015 Category: Consumer Health News Tags: Psychiatry Journal Article Source Type: news

Researchers find potential anti-cancer use for anti-epilepsy drug
A drug used widely to combat epilepsy has the potential to reduce the growth and spread of breast cancer, scientists have discovered. The team found that "repurposing" antiepileptic drugs, such as phenytoin, that effectively block the sodium channels, could provide a novel therapy for cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 27, 2015 Category: Science Source Type: news

Levetiracetam Prevents Seizures During CraniotomyLevetiracetam Prevents Seizures During Craniotomy
Levetiracetam (LEV) may be more effective than phenytoin (PHT) in preventing seizures during craniotomy in patients with brain tumors, a new study suggests. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 2, 2015 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Skin Reactions to Phenytoin Linked to Gene VariantsSkin Reactions to Phenytoin Linked to Gene Variants
Carriers of a genetic variant linked to reduced drug clearance have more than 10 times higher odds of developing adverse skin reactions to the antiepileptic drug, suggesting screening may flag risk. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - August 21, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Phenytoin Toxicity From Cocaine AdulterationPhenytoin Toxicity From Cocaine Adulteration
Phenytoin (PHT) is commonly used as a cocaine adulterant, but can lead to toxic effects. In this case, a patient developed PHT toxicity after ingesting adulterated crack cocaine. Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 1, 2014 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

Episode #4: Poisoning and the diagnosis of brain death
Conclusion: unclear how long to wait before pronouncing brain death as many factors such as pharmacogenetics can alter normal metabolism   Summary Drug overdose can mimic brain death Be especially cautious in overdose involving the scary B’s: baclofen, barbiturate, benzodiazepine The 3-5 half life rule for drug clearance cannot be applied in the cases of overdose Half lives are measured at therapeutic levels Multiple other factors can alter metabolism in overdoses, such as pharmacogenetics, and cross reactivity with other ingestants Consult a toxicologist if there is any question regarding possible overdose...
Source: The Poison Review - May 20, 2014 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

Good quick review of bupropion toxicity, but . . . whole bowel irrigation? Seriously??
2.5 out of 5 stars Bupropion Abuse and Overdose. Stall N et al. CMAJ 2014 Apr 28 [Epub ahead of print] No abstract available online This one-page précis is part of CMAJ‘s “Five Things To Know About _______” series. The key points include: Bupropion blocks reuptake of dopamine and norepinephrine, and also blocks the action of acetylcholine at nicotinic receptors. Burpropion is abused recreationally for its mild cocaine-like “high.” Routes of bupropion abuse include snorting, ingestion, and intravenous injection. Brupropion lowers the threshold for seizures, which may be d...
Source: The Poison Review - May 9, 2014 Category: Toxicology Authors: Leon Tags: Medical abuse bupropion overdose seizures Source Type: news

IV Sodium Valproate vs Phenytoin for Status EpilepticusIV Sodium Valproate vs Phenytoin for Status Epilepticus
Sodium valproate has been used to treat status epilepticus successfully, but its role as the first-line drug is still controversial. Is it as effective as I.V. phenytoin? BMC Neurology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 18, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Drug Reaction in a Patient on Phenytoin and LevetiracetamDrug Reaction in a Patient on Phenytoin and Levetiracetam
This case report highlights a potentially life-threatening hypersensitivity reaction -- the DRESS syndrome -- associated with a variety of medications, especially anti-epileptics. Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 17, 2013 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

FDA Updates Atazanavir Sulfate Capsule Labeling
“Recently [February 4, 2013] FDA approved changes to the Reyataz (atazanavir sulfate) capsule labeling to include the following changes. “Section 5 Warnings and Precautions was revised to include cholelithiasis ...   “In section 6 Adverse Reactions: Postmarketing Experience, interstitial nephritis was added. “In section 7 Drug Interactions: information regarding coadministration with boceprevir, carbamazepine, phenytoin, phenobarbital, lamotrigine and voriconazole was added.” The updated labeling will be available at the FDA website. More information is available: FDA: Press releas...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - February 12, 2013 Category: Infectious Diseases Source Type: news

BMJ letter: 'Another loophole exploited by the drug industry
Source: BMJ Area: News The author of this letter praises a recent analysis of the methods used by drug companies to maximise profits, but comments that a new tactic was omitted. This tactic exploits a loophole whereby the Department of Health is not involved in negotiations about the price of generic drugs, as these are usually driven down by market forces.   In September 2012 Pfizer sold the marketing rights of Epanutin® (phenytoin) to Flynn Pharma. Although the drug is identical (right down to the Epanutin stamp on the capsules), it is packaged under a different name and therefore can be described as generi...
Source: NeLM - News - February 4, 2013 Category: Drugs & Pharmacology Source Type: news