Urinary angiotensinogen excretion in Australian Indigenous and non-Indigenous pregnant women

Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Kirsty G. Pringle, Celine Corbisier de Meaultsart, Shane D. Sykes, Loretta J. Weatherall, Lyniece Keogh, Don C. Clausen, Gus A. Dekker, Roger Smith, Claire T. Roberts, Kym M. Rae, Eugenie R. LumbersAbstractThe intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. The excretion of RAS proteins was measured in non-Indigenous and Indigenous Australian women with uncomplicated or complicated pregnancies (preeclampsia, diabetes/gestational diabetes, proteinuria/albuminuria, hypertension, small/large for gestational age, preterm birth), and in non-pregnant non-Indigenous women.Non-Indigenous pregnant women with uncomplicated pregnancies, had higher uAGT/creatinine levels than non-Indigenous non-pregnant women (P < 0.01), and levels increased as pregnancy progressed (P < 0.001). In non-Indigenous pregnant women with pregnancy complications, uAGT/creatinine was suppressed in the third trimester (P < 0.01). In Indigenous pregnant women with uncomplicated preg...

Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research