Rapid Weight Gain, Decreased Insulin Sensitivity Found in Youth Taking SGAs for First Time

Within 12 weeks of starting treatment with low-dose aripiprazole, olanzapine, or risperidone, youth with disruptive behavioral disorders experienced significant increases in total body fat, according to astudy published today inJAMA Psychiatry. The study also found that youth treated with these second-generation antipsychotics (SGAs) experienced decreases in insulin sensitivity over the 12-week period.The findings point to the importance of continued monitoring for metabolic abnormalities when treating youth with antipsychotics.For the study, Ginger E. Nicol, M.D., of the Department of Psychiatry at Washington University School of Medicine in St. Louis and colleagues recruited antipsychotic-na ïve youth aged 6 to 18 with one or more psychiatric disorders and clinically significant aggression. A total of 144 youth were assigned to aripiprazole, olanzapine, or risperidone for 12 weeks. (According to the study authors, mean final antipsychotic doses were representative of pediatric practice patterns and below the doses typically used to treat psychosis: aripiprazole, 6.0 mg; olanzapine, 6.3 mg; risperidone, 1.0 mg.)The authors used dual X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) scans to assess changes in total body fat and abdominal fat over the course of the trial. At baseline and 12 weeks, the youth also received an insulin sensitivity test and answered questions about their symptoms.Although the youth experienced clinically and statistically signifi...
Source: Psychiatr News - Category: Psychiatry Tags: antipsychotic medications aripiprazole fat Ginger E. Nicol insulin sensitivity JAMA Psychiatry Johan Detraux Marc De Hert olanzapine risperidone weight gain Source Type: research

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ConclusionChildren ’s prevalence of overweight/obesity and eating attitudes improves soon after their mothers’ RYGB, but then return to pre-surgery levels at 4 years post-surgery, as do mothers’ sleep quality and symptoms of depression and anxiety, even though their weight loss was maintained.
Source: Obesity Surgery - Category: Surgery Source Type: research
The Centre is trying to plug a legal loophole that allows major drug manufacturers to sell and market products, such as emergency contraceptives and anti-obesity and fertility formulations, which haven ’t undergone clinical trials to establish their risk and efficacy.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
Authors: Kim JS, Kim KH, Kim WW Abstract OBJECTIVES: Acupuncture is increasing in popularity as a complementary and alternative medicine. Pneumothorax is the most common and potentially serious adverse effect after acupuncture. This complication can cause fatality in the absence of rapid treatment. Here, we analyze the clinical presentation and discuss prevention of post-acupuncture pneumothorax and an approach to reducing this complication. METHODS: Patients presenting with post-acupuncture pneumothorax in our hospital center during 2011-2015 were retrospectively analyzed. Body mass index (BMI), patient's pre-...
Source: Acupuncture and Electro-Therapeutics Research - Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research
As hard as it may sound to pull out of this stress reaction cycle, it is possible. The first step in creating any positive change is always raising your awareness of what the cycle is, how you participate in it, and what pains the cycle creates. Why? Because you can’t change a habit you don’t know you have. And if you don’t recognize the pain the habit is creating, you won’t have the motivation you need to make new choices and break out of the cycle that has become familiar despite the fact that it is destructive. The practice of mindfulness is an incredibly powerful tool to help you find that awa...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Agitation Anxiety and Panic General Habits Happiness Mindfulness Self-Help Stress Mindfulness Based Stress Reduction Stress Response Source Type: blogs
We read with great interest the letter to the Editor “Controversial points in the obesity paradox in patients with coronary artery disease” by Mehmet Eyuboglu [1]. We thank the author for the interesting considerations to our recently published paper [2]. We agree that the effect of weight loss on prognosis in patients with coronary heart disease (CHD) is heterogeneous and affected by factors in many aspects. Several major concerns have been raised by the author and will be addressed here.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Correspondence Source Type: research
ConclusionProlonged immobilization after abdominoplasty does not crucially lower the overall complication rate, but influences the severity of complications in a positive way. Increasing the duration of postoperative immobilization up to 45  h after abdominoplasty significantly decreases the reoperation rate in our practice. The risk for a surgical revision is nearly four times higher if the patient leaves bed earlier. Surgeons should consider this option especially in patients with a high risk for complication development.
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractEndoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis. The total sample was 459 patients (312 EBTs vs 147 control). Mean total b...
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractLaparoscopic adjustable gastric band (LAGB) placement remains a common bariatric procedure. While LAGB procedure is performed within private clinics in most Canadian provinces, public health care is often utilized for LAGB-related reoperations. We identified 642 gastric band removal procedures performed in Ontario from 2011 to 2014 using population-level administrative data. The number of procedures performed increased annually from 101 in 2011 to 220 in 2014. Notably, 54.7% of the patients required laparotomy, and 17.6% of patients underwent a subsequent bariatric surgery. Our findings demonstrated that LAGB place...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsLSG produces an improvement in lipid profile, with a significant increase in HDL and a decrease in LDL, triglycerides, and non-HDL-C.
Source: Obesity Surgery - Category: Surgery Source Type: research
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