18F-FDG PET-CT in the clinical management of cardiac sarcoidosis: A regional academic referral center experience.

Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following immunomodulator therapy. It is important to note the scans also revealed persistent pulmonary, as well as mediastinal and hilar nodal involvement.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research

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CONCLUSIONS: MLN enlargement predicts TFS and hospitalization risk in ILD, and is associated with decreased levels of a key circulating cytokine sCD40L. Incorporating MLN and cytokine findings into current prediction models might improve ILD prognostication. PMID: 30216085 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
CONCLUSIONS: FDG-PET scan can be used as an important adjunct non-invasive investigation in diagnosing and monitoring of various benign lung conditions. It also helps in assessing whole body disease burden which may change therapeutic decisions. PMID: 30152649 [PubMed - in process]
Source: Indian Journal of Chest Diseases and Allied Sciences - Category: Respiratory Medicine Tags: Indian J Chest Dis Allied Sci Source Type: research
Publication date: Available online 25 August 2018Source: Respiratory Medicine Case ReportsAuthor(s): Sho Shimada, Haruhiko Furusawa, Toshihisa Ishikawa, Eisaku Kamakura, Takafumi Suzuki, Yuta Watanabe, Takasato Fujiwara, Shinichiro Tominaga, Keiko Mitaka Komatsuzaki, Ichiro NatsumeAbstractA 60-year-old man visited our hospital for further examination of an abnormal chest radiograph. Computed tomography (CT) images revealed enlarged mediastinal lymph nodes and multiple pulmonary nodules.Further evaluation by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was performed and he was diagnosed with ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
CONCLUSION: EBUS-TBNA is associated with a risk of mediastinitis that may manifest as an isolated fever arising within hours of the procedure. The pathogens responsible are usually contaminants from the oropharynx such as Streptococcus sp, probably inoculated directly into the mediastinum during transbronchial needle aspiration. Rapid diagnosis and treatment are necessary in order to reduce morbidity and mortality associated with mediastinitis. PMID: 30098879 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
ConclusionNecrotising retinopathy-like lesions mimicking an infectious process or a lymphoproliferative disorder can be an atypical manifestation of ocular sarcoidosis.
Source: Journal of Ophthalmic Inflammation and Infection - Category: Opthalmology Source Type: research
Introduction We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (68Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity. Patients and methods Patients diagnosed with sarcoidosis underwent 68Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. A SUVmax/SUVmed ratio (disease activity score) of more than one was considered a marker of active disease and was compared with the clinical symptoms and serum angiotensin-converting ...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Daniele Cirone, Luca Cimino, Giovanni SpinucciAbstractSarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging.We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations.A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous...
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
Conclusions18F-FDG PET/CT is useful for differentiating benign and malignant SPNs in patients with IPF, as it is for patients without IPF.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Abstract The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a mat...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
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