18F-FDG PET-CT in the clinical management of cardiac sarcoidosis: A regional academic referral center experience.

Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following immunomodulator therapy. It is important to note the scans also revealed persistent pulmonary, as well as mediastinal and hilar nodal involvement.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research

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Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Abstract The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a mat...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
1542Objectives: Cardiac sarcoidosis (CS) is rare but a potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and most notably sudden cardiac death. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays important roles not only in the diagnosis of CS but also in the evaluation of therapeutic effects of anti-inflammatory therapy. A volume-based analysis by FDG PET including cardiac metabolic volume (CMV) has emerged as a new assessment tool for measuring the volume within the boundary determined by reference tissue such as the liver and the blood...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
Conclusions: Apart from the common capability of showing anatomic spread of disease in the whole body in one single examination for both TB and SC, in TB 18F-FDG seems to be a good predictor for the extent of disease by assessment of the highest SUV seen in any pathological lesion and for therapy control, too, as indicated in earlier work. In SC, FDG-uptake markedly focuses on lymph nodes, consistent with the natural history of the disease. However, we see uptake behavior clearly different from TB in respect of the prediction of disease extent and some other features. Evaluation of the relevance of these facts for initial ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
In conclusion, the present study shows that 18F-FDG PET/CT is an effective way to monitor the early therapeutic reaction and is helpful in predicting the long-term prognosis of sarcoidosis. PMID: 29686996 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionsA patient with neurosarcoidosis presenting with compressive ischemic optic disc edema and neovascular glaucoma is described, increasing the diversity of clinical presentations and confirming the diagnostic challenge of neurosarcoidosis.
Source: Journal of Ophthalmic Inflammation and Infection - Category: Opthalmology Source Type: research
ConclusionsAtypical manifestations of pulmonary sarcoidosis are diagnostically challenging because the clinical and radiographic features of the disease mimic those of a malignancy. We aimed to illustrate a unique etiology of a lung mass and the importance of maintaining a broad differential diagnosis. Nonetheless, with the possibility of a malignancy, a high index of suspicion is necessary for timely diagnosis and optimal management.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Authors: Tetikkurt C, Yanardag H, Pehlivan M, Bilir M Abstract Sarcoidosis is a systemic disease characterized by noncasefied granulomas in various organs. Incidence of splenic disease is variable and is reported to occur in 6.7 to 77 percent of the patients. Firm data establishing the clinical features and the association of splenic involvement with prognosis in sarcoidosis is scant. The aim of our study was to investigate the clinical features and the consequence of splenic involvement on the prognostic outcome of sarcoidosis patients. We evaluated the clinical and laboratory findings in 82 sarcoidosis patients. ...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Conclusions— Among patients with suspected CS, combining CMR and PET provides complementary value for estimating the likelihood of CS and guiding patient management.
Source: Circulation: Cardiovascular Imaging - Category: Radiology Authors: Tags: Inflammation, Cardiomyopathy, Inflammatory Heart Disease, Magnetic Resonance Imaging (MRI), Nuclear Cardiology and PET Cardiomyopathies Source Type: research
Publication date: Available online 4 January 2018 Source:Saudi Journal of Ophthalmology Author(s): Daniele Cirone, Luca Cimino, Giovanni Spinucci Sarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging. We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations. A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous anterior uve...
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
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