18F-FDG PET-CT in the clinical management of cardiac sarcoidosis: A regional academic referral center experience.
Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following immunomodulator therapy. It is important to note the scans also revealed persistent pulmonary, as well as mediastinal and hilar nodal involvement.
This article reviews how the SSTR-directed theranostic concept is currently applied and also reflects on recent developments that hold promise for the future of theranostics in this context.
In conclusion, using newer sensitive imaging tool we detected 36 (9.2%) patients with serious pathologies before the first symptoms. Therefore we believe, that ¹F-FDG PET/CT imaging can be recommended to be done not only in all MGUS patients with suspected SMM or active MM, but also for early identification of other serious pathologies.DisclosuresNo relevant conflicts of interest to declare.
We present here preliminary descriptive data on the patients' characteristics and their established diagnosis at follow-up.Methods: Since 2015, all patients aged ≥15 years and referred to the hematology or internal medicine department in 117 French hospitals, with an unexplained SM diagnosis (confirmed by echography or CT-scan with a craniocaudal length ≥13 cm) have been invited to participate. Unexplained cause of SM was defined as a first negative clinical workup based on patient's interview and physical examination, and biological routine tests (including complete blood and reticulocytes count, clotting test, live...
Sarcoidosis is a progressive multisystem disease which is primarily affecting the lungs and is characterized by epithelioid granulomas in various organs and tissues. It is suggested that the severity of sarcoidosis is determined by a violation of endithelial function.Aim: To determine the features of VEGF production during the active course of lung sarcoidosis.Materials and Methods: Twenty three patients with lung sarcoidosis were examined. The VEGF level was determined using ELISA (enzyme-linked immunosorbent assay) and test of R&D systems Kuantykine (USA). Comparisons were made with the morphological data and the results...
Conclusions: HRCT-scan have limitations if the objective is to accurate define interstitial lung diseases. Consequently, pathological assessing should be taken into account, in order to provide more accurate tailored treatment strategies.
This study aimed to evaluate the aforementioned tests, in order to examine the functional capacity of sarcoidosis patients, in different stages.Methods: This cross-sectional study carried out, on 50 Iranian patients with sarcoidosis. Patients were classified into three groups, based on the findings of the chest radiography, as well as the pulmonary CT scan, performed by an expert Radiologist; Pulmonary, cardiac and activity function have been evaluated in the patients, using CPET, 6MWT and spirometry.Results: In CPET, percent-predicted peak VO2, 57.75±15.49, p
Conclusion: CS therapy is a risk factor for sarcoidosis relapse. Therefore, despite their high efficacy, corticosteroids are recommended in asymptomatic patients only in cases of progressive disease or lack of improvement after 3 months follow-up period.
We describe a cohort of patients who have evidence of granulomatous inflammation during EBUS-TBNA (endobronchial ultrasound-guided transbronchial needle aspiration) done for the investigation of sarcoidosis and staging of a known lung cancer.Out of 800 EBUS performed between May 2010- Nov 2017, 500 yielded a benign diagnosis (men 55.6%). Rapid on-site evaluation by a cytopathologist was done in 82% of procedures and yielded a diagnosis in 86.8%.In the setting of suspected sarcoidosis (59.3%), the mean diagnostic yield was 61.05%, ATS Station 7 being the most commonly sampled lymph node (66.67%)Granulomatous inflammation wa...
CONCLUSION: The measurement of serum 25(OH)D and 1,25(OH)2D levels is a useful tool in the etiological workup of patients with unexplained uveitis, since a high 1,25(OH)2D/25(OH)D ratio is suggestive of ocular sarcoidosis. PMID: 30395752 [PubMed - as supplied by publisher]
We present a case of cardiac sarcoidosis with significantly impaired ejection fraction that was diagnosed late in the course of disease with complete metabolic response to therapy and an improvement of LV function, but with a subsequent complication of ventricular tachycardia storm.