Coordination of Pharyngeal and Laryngeal Swallowing Events During Single Liquid Swallows After Oral Endotracheal Intubation for Patients with Acute Respiratory Distress Syndrome

AbstractTo evaluate timing and duration differences in airway protection and esophageal opening after oral intubation and mechanical ventilation for acute respiratory distress syndrome (ARDS) survivors versus age-matched healthy volunteers. Orally intubated adult ( ≥ 18 years old) patients receiving mechanical ventilation for ARDS were evaluated for swallowing impairments via a videofluoroscopic swallow study (VFSS) during usual care. Exclusion criteria were tracheostomy, neurological impairment, and head and neck cancer. Previously recruited healthy volu nteers (n = 56) served as age-matched controls. All subjects were evaluated using 5-ml thin liquid barium boluses. VFSS recordings were reviewed frame-by-frame for the onsets of 9 pharyngeal and laryngeal events during swallowing. Eleven patients met inclusion criteria, with a median (interquartile range [IQR]) intubation duration of 14 (9, 16) days, and VFSSs completed a median of 5 (4, 13) days post-extubation. After arrival of the bolus in the pharynx, ARDS patients achieved maximum laryngeal closure a median (IQR) of 184 (158, 351) ms later than age-matched, healthy volunteers (p 
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Abstract Construction of hybrid systems that combine the cancer treatment and diagnosis agents on a single platform, known as theranostic systems, have received great attentions in the field of nanobiomedicine. Here, construction and characterization of a new multifunctional hybrid theranostic system based on RGO, PDA, BSA, DTPA-Mn(II), and MTX constituents, is presented. Accordingly, GO is partially reduced and simultaneously functionalized by dopamine, leading to reduced graphene oxide/polydopamine, RGO-PDA system; and then, the bovine serum albumin protein (BSA) is grafted onto this system. The obtained system,...
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Publication date: Available online 13 August 2018Source: European Journal of Surgical OncologyAuthor(s): João Gonçalves Filho, Mark E. Zafereo, Faisal I. Ahmad, Iain J. Nixon, Ashok R. Shaha, Vincent Vander Poorten, Alvaro Sanabria, Avi Khafif Hefetz, K. Thomas Robbins, Dipti Kamani, Gregory W. Randolph, Andres Coca-Pelaz, Ricard Simo, Alessandra Rinaldo, Peter Angelos, Alfio Ferlito, Luiz P. KowalskiAbstractThe central compartment is a common site for nodal spread from differentiated thyroid carcinoma, often occurring in patients without clinical or ultrasonographic (US) evidence of neck lymph node metastasi...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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Source: Annals of Surgery - Category: Surgery Tags: Papers of the 138Th ASA Annual Meeting Source Type: research
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Authors: Giannitto C, Preda L, Zurlo V, Funicelli L, Ansarin M, Di Pietro S, Bellomi M Abstract Head and neck squamous cell carcinoma is the sixth most common cancer diagnosed worldwide and the eighth most common cause of cancer death. Malignant tumors of the oral cavity, oropharynx, and larynx can be treated by surgical resection or radiotheraphy with or without chemotheraphy and have a profound impact on quality of life functions, including swallowing. When surgery is the chosen treatment modality, the patient may experience swallowing impairment in the oral and pharyngeal phases of deglutition. A videofluoroscop...
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