[Research Articles] A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration

We report an interim analysis of the phase 1 cohort consisting of five subjects. Four of five subjects enrolled in the study successfully received the composite implant. In all implanted subjects, optical coherence tomography imaging showed changes consistent with hESC-RPE and host photoreceptor integration. None of the implanted eyes showed progression of vision loss, one eye improved by 17 letters and two eyes demonstrated improved fixation. The concurrent structural and functional findings suggest that CPCB-RPE1 may improve visual function, at least in the short term, in some patients with severe vision loss from advanced NNAMD.

Source: Science Translational Medicine - April 4, 2018 Category: Biomedical Science Authors: Kashani, A. H., Lebkowski, J. S., Rahhal, F. M., Avery, R. L., Salehi-Had, H., Dang, W., Lin, C.-M., Mitra, D., Zhu, D., Thomas, B. B., Hikita, S. T., Pennington, B. O., Johnson, L. V., Clegg, D. O., Hinton, D. R., Humayun, M. S. Tags: Research Articles Source Type: research