O7.1. midbrain dopamine neuron activity controls the effects of repeated ketamine on striatal dopaminergic function

DiscussionOur data show that sub-chronic ketamine results in the elevation in striatal dopamine synthesis capacity and locomotor sensitization and that these effects require midbrain dopamine neuron activation. Furthermore, our data are in support of the hypothesis that NMDA receptor hypofunction on GABAergic interneurons leads to disinhibition of glutamatergic projections and subsequently increase in dopamine neuron activity and dopamine synthesis capacity in projection targets such as the striatum.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research