The JDRF and the Helmsley Charitable Trust Request Expressions of Interest for Improved Assays for Predicting Risk for T1D

The JDRF and the Helmsley Charitable Trust Request Expressions of Interest for Improved Assays for Predicting Risk for T1D JDRF and The Leona M. and Harry B. Helmlsey Charitable Trust are soliciting expressions of interest (EOI) for optimizing and validating existing technologies for predictive screening for T1D risk and autoimmunity to be applied for wide-spread use in population-based screening efforts, including newborn or childhood based screening. EOIs requesting development of new assays will not be considered. BACKGROUND Prevention of type 1 diabetes (T1D) represents a “cure” for those at-risk of developing the disease, and, in fact, will likely represent the most cost-effective approach to a cure and is becoming increasingly important with the rising incidence of the disease. Over the last three to four decades, the incidence of T1D has increased at an annual rate of 3-5% with penetration to low-moderate human leukocyte antigen (HLA) risk groups, suggesting a lowered threshold for its development. In some countries, the largest increase in incidence has occurred in the age group 1-5 years. Currently, assays of islet autoantibodies (AAb) are the most robust approach to detect risk in relatives of individuals with T1D and aid in predicting progression to T1D in HLA at-risk children. Indeed , the 10-year risk of progression to symptomatic T1D with multiple islet AAbs (insulin, GAD65, IA-2 and ZnT8) is 70%. However, the current practices for AAb screen...
Source: ScanGrants feed - Category: Research Authors: Source Type: funding

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In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsIn maternal type 1 diabetes pregnancies, fetal cardiovascular hemodynamics is impaired. Maternal type 1 diabetes does not seem to alter placental vascular impedance or induce placental inflammation.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL ARTICLE Source Type: research
Severe hypoglycemia is defined as a condition with serious cognitive dysfunction, such as a convulsion and coma, requiring external help from other persons. This condition is still lethal and is reported to be the cause of death in 4–10% in children and adolescents with type 1 diabetes. The incidence of severe hypoglycemia in the pediatric population was previously reported as high as more than 50–100 patient-years; however, there was a decline in the frequency of severe hypoglycemia during the past decades, and relationship with glycemic control became weaker than previously reported. A lot of studies have sho...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsIn maternal type 1 diabetes pregnancies, fetal cardiovascular hemodynamics is impaired. Maternal type 1 diabetes does not seem to alter placental vascular impedance or induce placental inflammation.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ud Berg T Abstract Objective: To assess the total prevalence of types 1 and 2 diabetes and to describe and compare cardiovascular risk factors, vascular complications and the quality of diabetes care in adults with types 1 and 2 diabetes in Salten, Norway. Research design and methods: Cross-sectional study including all patients with diagnosed diabetes in primary and specialist care in Salten, 2014 (population 80,338). Differences in cardiovascular risk factors, prevalence of vascular complications and attained treatment targets between diabetes types were assessed using regression analyses. Results: We identified...
Source: Scandinavian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Scand J Public Health Source Type: research
Purpose: To investigate hyperreflective foci (HF) on spectral-domain optical coherence tomography in patients with Type 1 diabetes mellitus across different stages of diabetic retinopathy (DR) and diabetic macular edema (DME) and to study clinical and morphological characteristics associated with HF. Methods: Spectral-domain optical coherence tomography scans and color fundus photographs were obtained of 260 patients. Spectral-domain optical coherence tomography scans were graded for the number of HF and other morphological characteristics. The distribution of HF across different stages of DR and DME severity were stu...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
In 1591 Italian subjects affected by SARS-COV-2, there was a prevalence of 17% of type 2 diabetes. In analogy to what has been shown in a Chinese population [2] and in another group of Italian subjects [3], surprisingly no cases with type 1 diabetes are apparently reported. This observation needs to be confirmed and further evaluated, for example in regions with high prevalence of the disease (Scandinavian, Finland or Sardinian), but there could be a number of reasons that justify a low incidence of SARS-COV-2 in subjects with type 1 diabetes.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Commentary Source Type: research
Conclusions: Detailed patient health information systems and genetic testing already exist and are helping with early diagnosis. Although in its early stages, pancreatic imaging excites the search for new tracers. 18F-VMAT22 and other potential ligands could solve a costly health concern of the American public. My personal experience illustrates that paediatric type 1 diabetes is far easier to diagnose and has a better prognosis than type two. Type two diabetes is heavily reliant on early diagnosis and novel approaches such as PET imaging could play an integral role in this early diagnosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Tech Students Papers II Source Type: research
Authors: Tiberti C, Panimolle F, Borghini R, Montuori M, Trovato CM, Filardi T, Lenzi A, Picarelli A Abstract Background: No data are available on the frequency of organ-specific humoral autoimmunity at diagnosis of adult celiac disease (CD).Aim: To evaluate the humoral immunoreactivities specific of type 1 diabetes (T1D), thyroid (THD), atrophic-gastritis (AG) and Addison's (AD) diseases in 92 adult CD patients at diagnosis and 237 adult healthy subjects (CTRL).Methods: T1D, THD and AD specific autoantibodies were analyzed by radioimmunoprecipitation assays. AG autoantibodies were detected by enzyme-linked immunos...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
ConclusionDespite the limited possibility to exercise and the incumbent psychologic stress, glycaemic control improved in patients with T1D who stopped working during the lockdown, suggesting that slowing down routine daily activities can have beneficial effects on T1D management, at least in the short term.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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