Conservation of Hearts from Brain Dead Donors with a Preservation Solution Supplemented by a Conditioned Medium from Mesenchymal Stem Cells, Improves Graft Contractility After Heart Transplantation in Rats

Heart transplantation remains the standard treatment for end stage heart failure patients. However, hemodynamic instability after brain death (BD) could affect posttransplant graft function. Conditioned medium (CM) from bone marrow derived mesenchymal stem cells (MSCs) was found to protect the myocardium against ischemia/reperfusion (IR), this finding appears to be mediated via activation of the phosphatidylinositol 3 kinase (PI3K) signalling. We hypothesized that CM added to a preservation solution (Custodiol) improves in vivo left ventricular (LV) graft function after transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research