Health perspectives of a bioactive compound curcumin: A review

Publication date: April 2018 Source:Trends in Food Science & Technology, Volume 74 Author(s): Abdur Rauf, Muhammad Imran, Ilkay Erdogan Orhan, Saud Bawazeer Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a is an important consituitents present in Curcuma longa L. (turmeric) rhizome. It is also a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. Being chemopreventive agent, curcumin has been found to modulate multiple molecular pathways through several mechanisms, e.g. induction of apoptosis, inhibition survival signals, and prevention from reactive oxidative species (ROS). Curcumin significantly caused reduction in lung cancer stem cells markers (CD133, ALDHA1, CD44, Nanog, and Oct4) and the number of CD133-positive cells as well as efficiently decreased the tumorsphere formation, inhibited proliferation, and induced apoptotic cell death. It also suppressed the activation of both Wnt/β-catenin and Sonic Hedgehog pathways. Curcumin has been also reported to diminish renal hypertrophy, reduce mesangial matrix expansion, and cause a lower level of albuminuria. It also inhibited the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices as well as significantly reduced the mature interleukin-1β, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research