L-Carnitine supplementation increases expression of PPAR- γ and glucose transporters in skeletal muscle of chronically and acutely exercised rats.

In this study, the effects of L-Carnitine supplementation on the lipid peroxidation and expression of PPAR-γ and glucose transporters in the liver and muscles of chronically and acutely exercised rats were investigated. A total of 42 male Wistar Albino rats (8-week-old) were divided into six groups as follows: Control, L-Carnitine, Chronic Exercise (CE), Chronic Exercise + L-Carnitine, Acute Exercise (AE) and L-Carnitine + Acute Exercise. Chronic exercise consists of 30 m/min, 30 min/day, and 5 days/week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. L-Carnitine was given at the level of 300 mg per kilogram of diet for 6 weeks. There was no significant difference in the levels of serum ALT, AST, urea, creatinine and glucose levels between the exercise and L-Carnitine groups (P > 0.05). Cholesterol and triglyceride levels decreased by L- carnitine supplementation and chronic exercise in control groups but increased in the AE groups compared to the control group without reinforcement (P < 0.05). Serum, muscle, heart, and liver malondialdehyde (MDA) concentrations were lower in CE and higher in the AE groups (P < 0.001). However, L-Carnitine supplementation reduced MDA levels (P < 0.05). Liver and muscle PPAR-γ, liver GLUT-2 and muscle GLUT-4 mRNA expressions were lower in AE group than in all other groups (P < 0.001). Both chronic exercise and supplemental L-Carnitine increased liver and muscle P...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Publication date: Available online 23 October 2018Source: Life SciencesAuthor(s): Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan Emel Usanmaz, Mecit Orhan Uludag, Emine Demirel-YilmazAbstractAimsLiver X receptors (LXRs) play an important role in the regulation of cholesterol, fatty acid and glucose metabolisms together with inflammatory processes. In the present study, the effects of LXR agonist GW3965 on vascular reactivity and expression of functional proteins in DOCA-Salt induced hypertension were examined.Main methodsHypertension was induced through unilateral nephrectomy and deoxycorticosterone-acetate (DOCA) injec...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2018Source: Pharmacological ResearchAuthor(s): Boyao Zhang, Volker M. LauschkeAbstractOrganic anion transporting polypeptides (OATP) encoded by the SLCO gene family constitute clinically important transporters involved in the disposition of endogenous compounds and many commonly prescribed drugs, including statins, methotrexate and antihypertensive medications. Common genetic polymorphisms in SLCO genes are known to affect OATP function and modulate efficacy and safety of OATP substrates. However, current frequency data of these variants and haplotypes is generally based on few...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
It’s so easy, anyone can do it! Becoming a type 2 diabetic and proudly having to finger stick your way to blood sugar control is patriotic, as it builds revenues for Big Pharma and the healthcare industry. What better way to support your country than to help successful industries grow larger, increase shareholder value, and increase the salary and perks for hard working executives? So if you want to join the growing ranks of people who are becoming diabetic, now the largest epidemic of chronic disease ever witnessed in the history of the world, here’s what you do: Cut your fat intake — Because it leaves ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates diabetes gluten gluten-free grain-free grains wheat belly Source Type: blogs
Publication date: December 2018Source: Journal of Functional Foods, Volume 51Author(s): Yongbo Peng, Yafang Wang, Qiukuan Wang, Xuan Luo, Yunhai He, Yuefan SongAbstractKjellmaniella crassifolia was cultured firstly in recent years in Dalian, China. To elucidate the hypolipidemic effects and functional mechanisms of fucoidan (KF) in K. crassifolia, hypolipidemic activities were studied using the established hyperlipemia Wistar rat model, corresponding chemical compositions and structures were analyzed. The results show that KF is 71.68% carbohydrate and 20.04% sulfate. The monosaccharides of KF mainly consist of fucose (31....
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This article focus on current studies and the possible anti-atherogenic mechanism related to apoA-IV, in order to provide a new therapeutic target for atherosclerotic cardiovascular diseases.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b09188
Source: Journal of the American Chemical Society - Category: Chemistry Authors: Source Type: research
Contributors : Carol Prives ; Scott W Lowe ; Sung-Hwan Moon ; Chun-Hao Huang ; Shauna L HoulihanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have discovered that loss of wild-type p53 correlates with elevated expression of mevalonate pathway genes in murine liver cancer and in human tumors. Mechanistically p53 blocks activation of SREBP-2, the master transcriptional regulator of this pathway, by transcriptionally inducing the ABCA1 cholesterol transporter gene, which inhibits SREBP-2 maturation. In mice the increase in mevalonate gene expression occurs in premalignant p53-null h...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Tumor-associated myeloid cells maintain immunosuppressive microenvironments within tumors. Identification of myeloid-specific receptors to modulate tumor-associated macrophage and myeloid-derived suppressor cell (MDSC) functions remains challenging. The leukocyte immunoglobulin-like receptor B (LILRB) family members are negative regulators of myeloid cell activation. We investigated how LILRB targeting could modulate tumor-associated myeloid cell function. LILRB2 antagonism inhibited receptor-mediated activation of SHP1/2 and enhanced proinflammatory responses. LILRB2 antagonism also inhibited AKT and STAT6 activation in t...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The metabolic-inflammatory crosstalk plays a key role in host defense against pathogens and inflammation. Guo and colleagues demonstrate that SCAP-SREBP2 complex integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling during inflammation.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research
Patients with hypertension may benefit from antihypertensive treatment with a calcium channel blocker and a lipid-lowering statin years after taking the medications, reported a long-term follow-upstudy in theLancet. Patients who received amlodipine-based antihypertensive treatment had fewer stroke deaths —independent of blood pressure levels—and patients taking lipid-lowering atorvastatin had fewer cardiovascular deaths.
Source: JAMA - Category: General Medicine Source Type: research
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