L-Carnitine supplementation increases expression of PPAR- γ and glucose transporters in skeletal muscle of chronically and acutely exercised rats.

In this study, the effects of L-Carnitine supplementation on the lipid peroxidation and expression of PPAR-γ and glucose transporters in the liver and muscles of chronically and acutely exercised rats were investigated. A total of 42 male Wistar Albino rats (8-week-old) were divided into six groups as follows: Control, L-Carnitine, Chronic Exercise (CE), Chronic Exercise + L-Carnitine, Acute Exercise (AE) and L-Carnitine + Acute Exercise. Chronic exercise consists of 30 m/min, 30 min/day, and 5 days/week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. L-Carnitine was given at the level of 300 mg per kilogram of diet for 6 weeks. There was no significant difference in the levels of serum ALT, AST, urea, creatinine and glucose levels between the exercise and L-Carnitine groups (P > 0.05). Cholesterol and triglyceride levels decreased by L- carnitine supplementation and chronic exercise in control groups but increased in the AE groups compared to the control group without reinforcement (P < 0.05). Serum, muscle, heart, and liver malondialdehyde (MDA) concentrations were lower in CE and higher in the AE groups (P < 0.001). However, L-Carnitine supplementation reduced MDA levels (P < 0.05). Liver and muscle PPAR-γ, liver GLUT-2 and muscle GLUT-4 mRNA expressions were lower in AE group than in all other groups (P < 0.001). Both chronic exercise and supplemental L-Carnitine increased liver and muscle P...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Authors: Xu Y, Li Z Abstract Adenosine triphosphate-binding cassette transporter A1 (ABCA1) gene polymorphism in lacunar infarction (LI) combined with arteriosclerosis was investigated. A total of 112 LI patients complicated with arteriosclerosis treated in Ningbo First Hospital from March 2015 to September 2016 were enrolled as observation group. At the same time, 342 healthy subjects were selected from physical examination center to serve as the control group. The ABCA1 gene polymorphism was detected via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the susceptibility of ABCA1...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
ConclusionsThis study suggests that there is no relationship between arterial stiffness and aerobic capacity in healthy young adults.
Source: Journal of Exercise Science and Fitness - Category: Sports Medicine Source Type: research
In this study, we uncover that miR-335-3p is significantly increased in aged cultured astrocytes and aged hippocampal brains, accompanied by decreased cellular cholesterol and diminished expression of HMGCR and HMGCS1, both step-limiting enzymes in cholesterol synthesis pathway. We also demonstrate that miR-335-3p suppresses HMGCS1 post-transcriptionally by directly binding to its 3’UTR, and HMGCR through binding mediated by SFRS2. More importantly, aged mice with miR-335-3p deficiency in hippocampal brains exhibit improved learning and memory, accompanied by enhanced levels of PSD95. We further reveal that the level...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 17 August 2018Source: Life SciencesAuthor(s): Saleh Rahmati-Ahmadabad, Hossein Shirvani, Abbass Ghanbari-Niaki, Fatemeh RostamkhaniAbstractAimsReverse cholesterol transport (RCT) is a process that prevents atherosclerosis. Studies showed that exercise training for strengthening cardiac muscle, increasing heart lipid metabolism and its potency against risk factors could protect cardiovascular health. Thus, the present study aims to investigate the effects of high intensity interval training (HIIT) on RCT and its related elements in plasma and tissues (liver and intestine) of rats.Materials...
Source: Life Sciences - Category: Biology Source Type: research
Conclusion: The critical role of domain-bulk differential lipid order modulation for erythrocyte reshaping is discussed in relation with the pressure exerted by the cytoskeleton on the membrane.Cell Physiol Biochem 2018;48:2563 –2582
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
CONCLUSION: The Korean Diabetes Risk Score may identify people at high risk of developing diabetes and may be an effective tool for delaying or preventing the onset of condition as risk management strategies involving modifiable risk factors can be recommended to those identified as at high risk. PMID: 30113144 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Conditions:   Acute Stroke;   Transient Ischemic Attack Interventions:   Drug: Dual antiplatelet;   Drug: Aspirin;   Drug: Early intensive statin;   Drug: Delayed intensive statin Sponsor:   Ministry of Science and Technology of the People´s Republic of China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
As part of the government's budget for 2018, Norwegian parliament (Storting) introduced the Medicine Start program to ensure the safe use of drugs for patients with chronic diseases. The program offers cardiovascular patients consultations with local pharmacists regarding their treatment with antihypertensive, cholesterol-lowering, or blood-thinning medications.        
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Source Type: research
Introduction Muscle force production is usually impaired in people with spinal cord injury (SCI). The use of high-intensity neuromuscular electrical stimulation (NMES) strength training can help promote metabolically active lean muscle mass and, thus, increase muscle mass and improve physical health and quality of life (QoL). Nonetheless, NMES is usually used at low-stimulation intensities, and there is limited evidence on the effects of high-intensity NMES strength training into improving muscle force and mass, symptoms of spasticity, or physical health and QoL in people with SCI. Methods Five individuals with chroni...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Clinical Sciences Source Type: research
Purpose Early and consistent evaluation of cardiac morphology and function throughout an atrophic stimulus is critically important for the design and optimization of interventions. This randomized controlled trial was designed 1) to characterize the time course of unloading-induced morphofunctional remodeling and 2) to examine the effects of exercise with and without low-dose testosterone supplementation on cardiac biomarker, structural, and functional parameters during unloading. Methods Twenty-six subjects completed 70 d of head-down tilt bed rest (BR): 9 were randomized to exercise training (Ex), 8 to EX and low-do...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: SPECIAL COMMUNICATIONS: Commentary Source Type: research
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