L-Carnitine supplementation increases expression of PPAR- γ and glucose transporters in skeletal muscle of chronically and acutely exercised rats.

In this study, the effects of L-Carnitine supplementation on the lipid peroxidation and expression of PPAR-γ and glucose transporters in the liver and muscles of chronically and acutely exercised rats were investigated. A total of 42 male Wistar Albino rats (8-week-old) were divided into six groups as follows: Control, L-Carnitine, Chronic Exercise (CE), Chronic Exercise + L-Carnitine, Acute Exercise (AE) and L-Carnitine + Acute Exercise. Chronic exercise consists of 30 m/min, 30 min/day, and 5 days/week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. L-Carnitine was given at the level of 300 mg per kilogram of diet for 6 weeks. There was no significant difference in the levels of serum ALT, AST, urea, creatinine and glucose levels between the exercise and L-Carnitine groups (P > 0.05). Cholesterol and triglyceride levels decreased by L- carnitine supplementation and chronic exercise in control groups but increased in the AE groups compared to the control group without reinforcement (P < 0.05). Serum, muscle, heart, and liver malondialdehyde (MDA) concentrations were lower in CE and higher in the AE groups (P < 0.001). However, L-Carnitine supplementation reduced MDA levels (P < 0.05). Liver and muscle PPAR-γ, liver GLUT-2 and muscle GLUT-4 mRNA expressions were lower in AE group than in all other groups (P < 0.001). Both chronic exercise and supplemental L-Carnitine increased liver and muscle P...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Conclusions: The present data show that plasma aldosterone is positively associated with LDL-C and non-HDL-C and inversely associated with HDL-C in the general population. Our data thus suggests that aldosterone concentrations within the physiological range may be related to alterations of lipid metabolism. PMID: 29780416 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Balsamic vinegar is a food cupboard staple in many kitchens. It can be used on roasted vegetables, salads, and as a marinade. In this article, we look at the many health benefits of balsamic vinegar, including reducing blood sugar, lowering cholesterol, and aiding weight loss. We also cover the possible risks.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Abstract Obesity and metabolic syndrome (MetS) are growing problems among children and adolescents. There are no reports of changes in the activity of butyrylcholinesterase (BChE) in children and adolescents with metabolic syndrome especially after supplementation with extract from Aronia melanocarpa. Materials studied included plasma and erythrocytes isolated from peripheral blood of patients with MetS and healthy subjects. We have estimated the following parameters: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, lipid peroxidation and lipids levels in plasma, and erythrocytes membrane. In...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Soft Matter, 2018, Accepted Manuscript DOI: 10.1039/C8SM00644J, PaperBing Bu, Michael Crowe, Jiajie Diao, Baohua Ji, Dechang Li Membrane fusion is a fundamental biological process that lies at the heart of enveloped virus infection, synaptic signaling, intracellular vesicle trafficking, gamete fertilization, and cell-cell fusion. Membrane fusion is initiated... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
That’s a bold statement—eat until you’re satisfied—in a world in which just about every nutritional authority tells you the opposite. But conventional advice was created by the uninformed to deal with appetite-stimulating opiate effects from wheat and grains. Remove wheat and grains and appetite recedes dramatically and calorie intake drops off without effort. There will be no mad scrambles for food due to overwhelming hunger, no sneaking ice cream in the middle of the night, no hidden snacks around the house. No more anxiously counting minutes until lunch or dinner. There will be no rolling, rumbli...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle belly fat blood sugar cholesterol consuming fat Dr. Davis energy grain grain-free meat red meat undoctored Weight Loss Wheat Belly Total Health Source Type: blogs
Confidence in the efficacy of statins to minimise the risk of life-threatening cardiovascular disease facilitates their  uptake.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Conclusions: Twelve weeks of treatment with topical testosterone or estrogen in postmenopausal women with symptoms of vaginal atrophy demonstrated laboratory and endometrial safety when compared with placebo.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Conclusion: Both LDL-C and inflammation reduction are beneficial to the reduction of CVD risk. However, canakinumab is a very expensive drug that only induced a 15% reduction in CVD events, thus drastically reducing the possibility for it to be used in clinical practice. Besides, canakinumab is associated with increased infections, some fatal. A potent statin with anti-inflammatory effects is probably the best choice for the majority of those needing hypolipidaemic drug therapy. PMID: 29785212 [PubMed]
Source: Open Cardiovascular Medicine Journal - Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research
Source: Cardiovascular and Haematological Disorders - Drug Targets - Category: Cardiology Authors: Tags: Review article Source Type: research
Bioprosthetic valve degeneration causes prosthetic valve failure like prosthetic valve thrombosis and pannus formation. Host related factors which predispose to bioprosthetic valve degeneration are: Younger age – hyperdynamic circulatory state in the young increases hemodynamic trauma Ejection fraction High blood pressure – increases hemodynamic load on the valve Chronic renal disease Smoking Diabetes mellitus Dyslipidemia – enhances deposition of oxidized LDL on the valve leaflets Valve related factors which cause bioprosthetic degeneration are the type of valve and correctness of implantation. Incorr...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
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