High-fat diet stimulates the gut pathogenic microbiota and maintains hepatic injury in antibiotic-treated rats.

High-fat diet stimulates the gut pathogenic microbiota and maintains hepatic injury in antibiotic-treated rats. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):103-106 Authors: Al-Daihan S, Ben Bacha A, Al-Dbass AM, Alonazi MA, Bhat RS Abstract The gut and the liver are closely linked to each other, as changes in the gut microbiota can play a significant role in the development of many liver diseases. Gut bacteria respond rapidly to changes in diet and thus can affect the liver through their metabolites. The impact of a high lipid diet on the liver in the presence of an altered gut flora modulated by ampicillin was investigated. The study was performed on 30 male Western albino rats randomly divided into 3 groups: control (phosphate buffered saline treated), group II (ampicillin 50 mg/kg for three weeks to induce microbiota alterations and fed on standard diet) and group III (same dose of ampicillin and fed on a lipid rich diet). Stool samples were collected for qualitative determination of bacteria. Serum hepato-specific markers, in addition to Glutathione (GSH), Lipid peroxidase (MDA), Glutathione-S- transferase(GST), and vitamin C in liver tissues, were measured. Altered gut microbiota significantly increased the level of the hepato-specific marker MDA and reduced the GST, GSH and vitamin C levels. However, animals fed a lipid rich diet displayed a more significant shift in hepatic markers and antioxidants. Moreover, a new switch in composition of th...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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AbstractPurpose of ReviewThe goal of this paper is to review current literature on nutritional ketosis within the context of weight management and metabolic syndrome, namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and describe nutritional ketosis.Recent FindingsNutritional ketosis has been found to improve metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting insulin and glucose levels, and aid in weight management. We discuss these findings and elaborate ...
Source: Current Nutrition Reports - Category: Nutrition Source Type: research
Hepatology,Volume 0, Issue ja, -Not available-.
Source: Hepatology - Category: Internal Medicine Authors: Source Type: research
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Source: Liver International - Category: Gastroenterology Authors: Source Type: research
Conclusion This study provides a detailed, large-scale picture of the relationship between the shape of the alcohol market in local areas and the levels of alcohol-related hospital admissions in those areas.  It suggests that there is a relationship, and that it is marked especially where there is a high density of any on-trade outlets or licensed convenience stores.  It suggests that this relationship is largely the same for men and women, and applies is a similar fashion irrespective of the relative affluence of a given area. It also suggests that while alcohol outlet density is already high across England, inc...
Source: Alcohol Research UK - Category: Addiction Authors: Tags: Alcohol Insights Source Type: news
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease. Exp Ther Med. 2018 Aug;16(2):1087-1094 Authors: Han M, Zhang T, Gu W, Yang X, Zhao R, Yu J Abstract Previous studies have suggested that 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) prevents progression of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The present study aimed to evaluate whether TSG could reverse NAFLD induced by a methionine and choline-deficient (MCD) diet and identify the possible mechanism of action. C5...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
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