A high-throughput screening of a chemical compound library in ovarian cancer stem cells.

CONCLUSION: Interestingly there were compounds active only on stem cells, only on differentiated cells and compounds active on both cell populations. Even if these data need to be validated in ad hoc dose response cytotoxic experiments, the ongoing analysis of the compound structures will open up to mechanistic drug studies to select compounds able to improve the prognosis of ovarian cancer patients.
PMID: 29366408 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - January 23, 2018 Category: Chemistry Authors: Ricci F, Carrassa L, Christodoulou MS, Passarella D, Michel B, Benhida R, Martinet N, Hunyadi A, Ioannou E, Roussis V, Musso L, Dallavalle S, Silvestri R, Westwood N, Mori M, Ingallina C, Botta B, Kavetsou E, Detsi A, Majer Z, Hudecz F, Bosze S, Kaminska Tags: Comb Chem High Throughput Screen Source Type: research