Protein-C reactive as biomarker predictor of schizophrenia phases of illness? A systematic review.

Protein-C reactive as biomarker predictor of schizophrenia phases of illness? A systematic review.
Curr Neuropharmacol. 2018 Jan 19;:
Authors: Orsolini L, Sarchione F, Vellante F, Fornaro M, Matarazzo I, Martinotti G, Valchera A, Di Nicola M, Carano A, Di Giannantonio M, Perna G, Olivieri L, De Berardis D
Abstract
BACKGROUND: Schizophrenia is a complex illness in which genetic, environmental, and epigenetic components have been implicated. However, recently, psychiatric disorders appear to be related to a chronic inflammatory state, at the level of specific cerebral areas which have been found as well impaired and responsible of the schizophrenia symptomatology. Hence, a role of inflammatory mediators and cytokines has been as well supposed. Accordingly, it has been recently investigated the role of an acute inflammatory phase protein, the C-reactive protein (CRP).
OBJECTIVE: Objective of the present study is evaluating how PCR may represent a biomarker in schizophrenia, i.e. correlated with illness phases and/or clinical manifestation and/or psychopathological severity.
METHOD: A systematic review was here carried out by searching the following keywords ((C-reactive protein AND ((schizophrenia) OR (psychotic disorder))) for the topics 'PCR' and 'Schizophrenia', by using MESH terms.
RESULTS: An immune dysfunction and inflammation have been described amongst schizophrenic patients. Findings reported elevated CR...

Source: Current Neuropharmacology - January 19, 2018 Category: Drugs & Pharmacology Authors: Orsolini L, Sarchione F, Vellante F, Fornaro M, Matarazzo I, Martinotti G, Valchera A, Di Nicola M, Carano A, Di Giannantonio M, Perna G, Olivieri L, De Berardis D Tags: Curr Neuropharmacol Source Type: research