Reply to “The role of NAFLD in extrahepatic malignancies: the importance of ruling out the effect of obesity”
We appreciate Bo Zheng et al. for their interest in our study and for providing a valuable comment. Our study investigated the little understood relationship between non-alcoholic fatty liver disease (NAFLD) and extrahepatic cancers , and found that NAFLD was highly associated with the development of hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females. This association suggests that NAFLD can serve as a risk factor of extrahepatic malignancies.
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (siRNAs) in human cancer, several cell lines (lung cancer, breast cancer and pancreatic cancer) were subjected to Agilent whole genome microarrays.
Authors: Obón-Azuara B, Gasch-Gallén Á, Gutiérrez-Cía I, Tomás-Aznar C PMID: 29907263 [PubMed - as supplied by publisher]
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ01973H, PaperXue Bai, Xudong Zhang, Haixin Gu, Fengjie Li, Wei Huang, Lu Liang, Zhengfang Ye PVA-SH microspheres could selectively detect Cu2+ by visible color change. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Abstract Opisthorchiasis is a neglected tropical disease, caused by infection with the fish-borne trematode Opisthorchis viverrini sensu lato that afflicts more than 10million people in Southeast Asia, including Thailand, Lao PDR, Vietnam and Cambodia. The disease is characterized by a chronic infection that induces hepatobiliary inflammation, especially periductal fibrosis, which can be detected by ultrasonography. This chronic inflammation eventually leads to cholangiocarcinoma (CCA), a usually fatal bile duct cancer that develops in approximately 1% of O. viverrini-infected individuals. In Thailand alone, CCA k...
Abstract Innate, inflammatory responses towards persistent Opisthorchis viverrini (OV) infection are likely to contribute to the development of cholangiocarcinoma (CCA), a liver cancer that is rare in the West but prevalent in Greater Mekong Subregion countries in Southeast Asia. Infection results in the infiltration of innate immune cells into the bile ducts and subsequent activation of inflammatory immune responses that fail to clear OV but instead may damage local tissues within the bile ducts. Not all patients infected with OV develop CCA, and so tumourigenesis may be dependent on multiple factors including th...
Abstract Opisthorchiasis is a neglected tropical disease of major proportion, caused by the carcinogenic, Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is known to be associated with malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Southeast Asia. No vaccine is available, and only one drug (praziquantel) is routinely employed against the parasite. Despite technological advances, little is known about the molecular biology of the fluke itself and the disease complex that it causes in humans. The advent of high-throughput nucleic acid sequencing and bioinformatic t...
Forensic science regulator launches investigation into a number of expert witnessesThe “smoke and mirror” tactics of defence lawyers in drink-driving cases have been criticised by the government’s forensic science regulator, who has launched an investigation into the work of a number of expert witnesses.The review was triggered by a recent high court judgment that raised concerns about defence teams requesting the disclosure of vast amounts of “irrelevant” technical information in order to challenge the reliability of breathalyser and blood alcohol test results.Continue reading...
We read with great interests the article by Gi-Ae et al. Non-alcoholic fatty liver disease(NAFLD) is strongly associated with metabolic disorders such as insulin resistance, diabetes and cardiovascular diseases which implies that NAFLD might have an important part in extrahepatic complications. Gi-Ae et al not only confirmed that NAFLD is closely related to the development of hepatocellular carcinoma but also demonstrated that NAFLD is a risk factor for extrahepatic malignancies such as male colorectal carcinoma and female breast cancer.
We thank Bo Zheng et al. for their interest in our study and for providing a valuable comment.1 Our study investigated the little understood relationship between non-alcoholic fatty liver disease (NAFLD) and extrahepatic cancers,2 and found that NAFLD was highly associated with the development of hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females. This association suggests that NAFLD can serve as a risk factor of extrahepatic malignancies.
We read with great interest the article by Kim et al.1 Non-alcoholic fatty liver disease (NAFLD) is strongly associated with metabolic disorders such as insulin resistance, diabetes and cardiovascular disease, suggesting that NAFLD is an important factor in extrahepatic complications. Kim et al. not only confirmed that NAFLD is closely related to the development of hepatocellular carcinoma, but also demonstrated that NAFLD is a risk factor for extrahepatic malignancies such as male colorectal carcinoma and female breast cancer.
More News: Alcoholism | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Colorectal Cancer | Fatty Liver Disease (FLD) | Gastroenterology | Hepatocellular Carcinoma | Liver | Liver Cancer | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Study | Urology & Nephrology