Reply to “The role of NAFLD in extrahepatic malignancies: the importance of ruling out the effect of obesity”

We appreciate Bo Zheng et al. for their interest in our study and for providing a valuable comment. Our study investigated the little understood relationship between non-alcoholic fatty liver disease (NAFLD) and extrahepatic cancers [1], and found that NAFLD was highly associated with the development of hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females. This association suggests that NAFLD can serve as a risk factor of extrahepatic malignancies.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research

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The public health burden of alcohol use disorder is experienced globally, yet the heterogeneous clinical presentation of this disorder and the spectrum of pathophysiology associated with its various disease stages have made it difficult —despite auspicious animal models—to bring forth efficacious pharmacotherapies that improve clinical outcome. This particularly complex field of therapeutic drug development calls for better strategies to expand drug targets and to optimize their use.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
The report finds that many existing policies and regulations aimed at tackling food marketing to children are markedly insufficient.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
In this study, we further explored the mechanism underlying CD133-mediated cisplatin resistance in glioblastoma stem cells. We sorted human glioblastoma T98G and U87MG cells into CD133+ and CD133− pools and measured apoptosis and CD133 expression levels in response to cisplatin treatment. We predicted candidate microRNAs that might target CD133 and assessed their levels in cisplatin-treated CD133+ cells. Finally, we overexpressed miR-29a in CD133+ cells and tested its effects in cisplatin-mediated apoptosis and survival of CD133+ tumor bearing mice receiving cisplatin treatment. We found that CD133+ glioblastoma stem...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
In conclusion, molecular alterations in ependymoma involve miRNAs. In our report, we review the level of evidence for the biomarker candidacy of identified miRNAs. Confirmatory studies are necessary to establish robust biomarkers for the clinical management of ependymoma. Proteins regulated by differentially expressed miRNAs are additional candidate biomarkers and may offer targets for novel therapeutic interventions.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: In conclusion, our study demonstrated that SCH-527123, a small-molecule antagonist for CXCR1 and CXCR2 inhibited cell proliferation, migration and invasion in melanoma via PI3K/AKT pathway. PMID: 30340844 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Ansari MZ, Tolstoy R, Jagadeeswaran G Abstract Thrombocytopenia is a common complication in patients with chronic liver disease and is multi-factorial. It complicates the management and worsens the prognosis. Treatment options are costly and include platelet transfusion, splenectomy, splenic artery embolization, TIPPS and thrombopoietin (TPO) agonists. Here we are presenting a patient with decompensated liver disease with known chronic alcoholism and profound thrombocytopenia despite multiple platelet transfusions. On further work up we found a coexistent autoimmune etiology. Thrombocytopenia promptly resp...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Krishnan M, Thampi A, Baite JP, Arul P PMID: 30341875 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
We read with great interests the article by Gi-Ae et al[1]. Non-alcoholic fatty liver disease(NAFLD) is strongly associated with metabolic disorders such as insulin resistance, diabetes and cardiovascular diseases which implies that NAFLD might have an important part in extrahepatic complications. Gi-Ae et al not only confirmed that NAFLD is closely related to the development of hepatocellular carcinoma but also demonstrated that NAFLD is a risk factor for extrahepatic malignancies such as male colorectal carcinoma and female breast cancer.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
We thank Bo Zheng et al. for their interest in our study and for providing a valuable comment.1 Our study investigated the little understood relationship between non-alcoholic fatty liver disease (NAFLD) and extrahepatic cancers,2 and found that NAFLD was highly associated with the development of hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females. This association suggests that NAFLD can serve as a risk factor of extrahepatic malignancies.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the article by Kim et al.1 Non-alcoholic fatty liver disease (NAFLD) is strongly associated with metabolic disorders such as insulin resistance, diabetes and cardiovascular disease, suggesting that NAFLD is an important factor in extrahepatic complications. Kim et al. not only confirmed that NAFLD is closely related to the development of hepatocellular carcinoma, but also demonstrated that NAFLD is a risk factor for extrahepatic malignancies such as male colorectal carcinoma and female breast cancer.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
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