Decreased Expression of Arginine-Phenylalanine-Amide-Related Peptide-3 Gene in Dorsomedial Hypothalamic Nucleus of Constant Light Exposure Model of Polycystic Ovarian Syndrome.

CONCLUSION: Constant light model of the PCOS-induced rats decreased the gene expression of RFRP3 in the DMH that suggests the decrease of RFRP3 may reduce its inhibitory effect on GnRH during the PCOS pathogenesis. This effect was stronger in the nulliparous rats than the primiparous.
PMID: 29334206 [PubMed]

Source: Cancer Control - January 17, 2018 Category: Cancer & Oncology Authors: Shaaban Z, Jafarzadeh Shirazi MR, Nooranizadeh MH, Tamadon A, Rahmanifar F, Ahmadloo S, Ramezani A, Javad Zamiri M, Razeghian Jahromi I, Sabet Sarvestani F, Koohi Hosseinabadi O Tags: Int J Fertil Steril Source Type: research