High-risk TP53 mutations are associated with extra nodal extension (ENE) in oral cavity squamous cell carcinoma (OSCC).

CONCLUSIONS: ENE is one of the most significant markers of OSCC OS and DFS. There is a shift toward a more aggressive biological phenotype associated with high-risk mutations of the TP53 gene. Prospective clinical trials are required to determine whether TP53 mutational status can be used for personalized treatment decisions.
PMID: 29330202 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 12, 2018 Category: Cancer & Oncology Authors: Sandulache VC, Michikawa C, Kataria P, Gleber-Netto FO, Bell D, Trivedi S, Rao X, Wang J, Zhao M, Jasser SA, Myers JN, Pickering CR Tags: Clin Cancer Res Source Type: research