Scientists develop new artificial ovary prototype

(Springer) Belgian researchers have taken important steps towards creating transplantable artificial ovaries. Once successful, these could be of value to women struggling with infertility or cancer patients who cannot conceive after undergoing radiation or chemotherapy. The research team has identified a protein formulation that closely resembles the structure and rigidity of the natural tissue lining a woman's ovaries, says Marie-Madeleine Dolmans of the Universit é Catholique de Louvain in Belgium, in an article in Springer's Journal of Assisted Reproduction and Genetics.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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The world’s first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet. Uterus transplants have become more common in recent years, resulting in 11 live births around the world. But all of the other successful deliveries so far have been made possible by living donors — often women who opt to donate their uterus to a close friend or family member without one. The birth resulting from the case detailed in the Lancet, which took place at Brazil’s Hospital das Cli╠ünicas last December, is both the first...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility healthytime Source Type: news
Conclusion: The DPP is the new source of non-toxic anti-cancer agents to use as a dietary supplement in the pre-treatment of cancer. PMID: 30397583 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
Authors: Cui W, Stern C, Hickey M, Goldblatt F, Anazodo A, Stevenson WS, Phillips KA Abstract Alkylating chemotherapy is often used to treat pre-menopausal women for various malignancies and autoimmune diseases. Chemotherapy-associated ovarian failure is a potential consequence of this treatment which can cause infertility, and increases the risk of other long term adverse health sequelae. Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in preventing chemotherapy-associated ovarian...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
(Abstracted from Reprod Biomed Online 2018;36:543–551) With the increasing incidence of cancer and survival rates among young women, the development of fertility preservation techniques is of critical importance for those who desire future pregnancy. The pattern of ovarian response and oocyte quality after ovarian stimulation in cancer patients of reproductive age has been studied in several retrospective studies, which often compared cancer patients with a historical control; results were mixed.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
(Abstracted from Reprod Biomed Online 2018;36:711–718) A late marker for the resumption of follicle growth after chemotherapy is the final recovery of menstrual activity. This can be monitored by measuring concentrations of anti–müllerian hormone (AMH), which is a real-time indicator of both follicular depletion and renewal of growth.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
From a historical perspective, the main clinical and research focuses have been on the long-term health outcomes of infertile women, including the effects of ovarian stimulation on the risk of mortality and cancer. However, in recent years, it has become more evident that a man's reproductive and somatic health also are closely related.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
AbstractWomen with a germline pathogenic variant in the BReast CAncer susceptibility genes (BRCA1 orBRCA2) have an increased risk of early-onset breast and ovarian cancer. In addition to weighing cancer screening and risk-reduction options, healthy BRCA mutation carriers of childbearing age may choose to preclude passing the mutation to the next generation. In the current study, we report on preimplantation genetic diagnosis (PGD) practices in BRCA-positive Israeli women who were offered PGD at no cost. Methods: we measured PGD uptake, decision satisfaction or regret, and predictors of uptake. Of the 70 participant female ...
Source: Journal of Genetic Counseling - Category: Genetics & Stem Cells Source Type: research
A lot of people are very worried whether IVF is safe or not, and many infertile couples are not allowed to do IVF by their family members, because they are concerned about the side effects of IVF - both on the mother , and the baby. After all, they believe that in an IVF cycle we're pumping the mother full of powerful hormonal injections – surely these are going to have some adverse effects on the body.Thus, many people believe that these hormones increase the risk of breast cancer and ovarian cancer ; or that an IVF patient will run out of eggs faster and become menopausal sooner, because the IVF cycle “ uses ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Conclusion: The patients of SLCT can present with hormonal magnification and manifest high AFP, CA125, and T levels. SLCT is characterized by a solid or mixed solid-cystic mass on CT/MR scans, and shows marked or moderated heterogeneous and constantly enhancement upon postcontrast study. The clinical characteristics and imaging findings are features and appropriated imaging should be performed whenever an SLCT is suspected.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
ConclusionThis study is at the best of our knowledge the first nationwide survey to assess the state of the art in oncofertility management. It highlights inadequate management of fertility preservation for female patients in France. Physicians reported lacking knowledge and tools that would allow them to provide patients with appropriate information. A better collaboration between cancer and fertility centers needs to be organized in France as already organized in other countries.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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