Journey of 2'-deoxy-2'-fluoro-5-methyl-1- β-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent.
CONCLUSION: While FMAU was not successful as an antiviral agent, 18F-FMAU is a suitable radiotracer for early detection of cancer and assessment of response to therapy by PET. The process of clinical grade 18F-FMAU production requires further improvement. 18F-FMAU has high potential for clinical application, but further extensive studies are needed to establish this tracer in diagnosis of various cancers and assessment of their response to therapy.
PMID: 29189119 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Alauddin MM Tags: Curr Med Chem Source Type: research
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