Danny ’s journey to a biventricular heart

The first hint that something wasn’t quite right with Danny Sanchez-Garcia’s heart came at his mom’s six-month prenatal visit. “There was a little blip on the ultrasound, but then it was gone on the next one, so they didn’t think it was anything and I didn’t worry any more about it,” says Danny’s mom, Cynthia. Cynthia was overjoyed when Danny was born at her local hospital seeming perfectly healthy. But as the hospital staff monitored Danny overnight, they noticed his oxygen level was lower than normal and decided to run more tests. His doctors believed the tests pointed to a congenital heart defect called tetralogy of Fallot with pulmonary atresia. “They transported him overnight to Boston Children’s Hospital,” says Cynthia. “I felt like I was on a roller coaster, especially as a first-time mom.” More tests and a new diagnosis Once Danny arrived at Boston Children’s, his story took another unexpected twist. Dr. Roger Breitbart, chief of Inpatient Cardiology, explained to Cynthia that Danny’s initial diagnosis was not correct. Upon more in-depth testing, Breitbart and his colleagues found that Danny had heterotaxy syndrome with double outlet right ventricle, pulmonary atresia and viscero-atrial situs inversus (abnormal connections of the large veins that return high-oxygen and low-oxygen blood to the heart). Heterotaxy is a rare, complex condition where the heart or other organs are not ...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories Biventricular Repair Complex Biventricular Repair Program congenital heart valve program double outlet right ventricle Dr. Christopher Baird Dr. Roger Breitbart ECMO Pulmonary atresia tetra Source Type: news

Related Links:

Publication date: Available online 30 May 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Leticia Alvarez-Sarrado, Carlos De Bonrostro-Torralba, Andrea Espiau-Romera, Marta Benito-Vielba, Ana Lasierra-Beamonte, Jose Manuel Campillos-Maza
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 30 May 2020Source: Journal of Dental SciencesAuthor(s): Rami Albahri, Hyung-In Yoon, Jason D. Lee, Sena Yoon, Sang J. Lee
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
Authors: Rong LQ, Neuburger PJ, Kim J, Devereux RB Abstract Global longitudinal strain (GLS) has emerged as a valuable diagnostic and prognostic tool for evaluating left ventricular (LV) function. GLS has been shown to be a more sensitive marker of LV dysfunction than LV ejection fraction alone and have prognostic impact in non-surgical cardiac populations. GLS, is validated, reproducible, and easily obtained from 2-dimensional speckle- tracking echocardiography. While there is strong evidence for using GLS in clinical decision- making in non-surgical populations, there is less summarized evidence on using GLS in t...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Pembrolizumab outperformed chemotherapy in patients with microsatellite-instability high/mismatch repair-deficient metastatic colorectal cancer in the KEYNOTE-177 study.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Authors: Oszukowska M, Kozłowska M, Kaszuba A Abstract Introduction: Psoriasis is considered as a risk factor for atherosclerosis and contributes to myocardial infarction, ischemic heart disease and brain stroke. Aim: To estimate the atherogenic potential of psoriasis by analysing antioxidative and prooxidative factors (paraoxonase-1, α-tocopherol, uric acid, homocysteine), compare levels of these parameters between groups of psoriatic patients and healthy individuals as well as to analyse the impact of psoriasis severity and duration on the factors under the study and to define correlation between the m...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Conclusions: Patients were well informed about MMR/MSI testing. Increased education of testing benefits and addressing financial barriers may help to further improve testing rates. PMID: 32468869 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
In conclusion, AK094629 knockdown attenuated the expression of IL‑1β‑regulated IL‑6 in the SMSCs of the temporomandibular joint by inhibiting MAP3K4. Therefore, AK094629 may be a potential novel therapeutic target for the treatment of temporomandibular joint osteoarthritis. PMID: 32468015 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
c‑Abl‑mediated tyrosine phosphorylation of DNA damage response proteins and implications in important cellular functions (Review). Mol Med Rep. 2020 May 18;: Authors: Bohio AA, Wang R, Zeng X, Ba X Abstract Tyrosine phosphorylation is an essential post‑translational protein modification catalyzed by tyrosine kinases. c‑Abl is a crucial non‑receptor tyrosine kinase, which is most commonly activated by auto‑phosphorylation, DNA damage and by interacting with other protein kinases. DNA damage response (DDR) proteins stimulated by DNA lesions or chromatin alterations recruit the DNA repair and ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Wood SH, Sills ES Abstract The inverse correlation between maternal age and pregnancy rate represents a major challenge for reproductive endocrinology. The high embryo ploidy error rate in failed in vitro fertilization (IVF) cycles reflects genetic misfires accumulated by older oocytes over time. Despite the application of different follicular recruitment protocols during IVF, gonadotropin modifications are generally futile in addressing such damage. Even when additional oocytes are retrieved, quality is frequently poor. Older oocytes with serious cytoplasmic and/or chromosomal errors are often harvested f...
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
Contributors : Xiao-Hong Sun ; Constantin GeorgescuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGroup 2 innate lymphoid cells (ILC2s) represent a subset of newly discovered immune cells that are involved in immune reactions against microbial pathogens, host allergic reactions as well as tissue repair. The basic helix-loop-helix transcription factors collectively called E proteins powerfully suppress the differentiation of ILC2s from bone marrow and thymic progenitors while promoting the development of B and T lymphocytes. How E proteins exert the suppression is not well understood....
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
More News: Anatomy | Atresia | Babies | Babies Heart Conditions | Blogging | Cardiac Catheterization | Cardiology | Children | Emergency Medicine | Gastroschisis Repair | Heart | Heart Disease | Heart Transplant | Heart Valve Disease | Heart Valve Surgery | Heart Valves | Hospitals | Learning | Lung Transplant | Pediatrics | Ultrasound | Universities & Medical Training