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Danny ’s journey to a biventricular heart

The first hint that something wasn’t quite right with Danny Sanchez-Garcia’s heart came at his mom’s six-month prenatal visit. “There was a little blip on the ultrasound, but then it was gone on the next one, so they didn’t think it was anything and I didn’t worry any more about it,” says Danny’s mom, Cynthia. Cynthia was overjoyed when Danny was born at her local hospital seeming perfectly healthy. But as the hospital staff monitored Danny overnight, they noticed his oxygen level was lower than normal and decided to run more tests. His doctors believed the tests pointed to a congenital heart defect called tetralogy of Fallot with pulmonary atresia. “They transported him overnight to Boston Children’s Hospital,” says Cynthia. “I felt like I was on a roller coaster, especially as a first-time mom.” More tests and a new diagnosis Once Danny arrived at Boston Children’s, his story took another unexpected twist. Dr. Roger Breitbart, chief of Inpatient Cardiology, explained to Cynthia that Danny’s initial diagnosis was not correct. Upon more in-depth testing, Breitbart and his colleagues found that Danny had heterotaxy syndrome with double outlet right ventricle, pulmonary atresia and viscero-atrial situs inversus (abnormal connections of the large veins that return high-oxygen and low-oxygen blood to the heart). Heterotaxy is a rare, complex condition where the heart or other organs are not ...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories Biventricular Repair Complex Biventricular Repair Program congenital heart valve program double outlet right ventricle Dr. Christopher Baird Dr. Roger Breitbart ECMO Pulmonary atresia tetra Source Type: news

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ConclusionsThe questionnaire was a pioneer initiative in the CdCS support group, and the answers used in this study can improve the health care assistance to these patients because they focus attention on the demands from a parental perspective. In addition, nearly half of the families stated that they did not remember information regarding recurrence risk, which reinforces the importance of genetic counselling follow‐up and the need for the expansion of genetic services in Brazil
Source: Journal of Intellectual Disability Research - Category: Disability Authors: Tags: Original Manuscript Source Type: research
AbstractAs one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles in health and disease. This review summarizes our current understanding of neutrophil-associated tissue injury, highlighting the emerging roles of neutrophil extracellular traps. This review will also focus on scrutinizing...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Conclusion: The proposed methodology for $IAA$ estimation, which corrects for the possible phase reversal on TWA after the presence of VPCs, represents a robust TWA estimation approach with a significant impact on the prognostic value of $IAA$ for SCD stratification in CHF patients. Significance: An accurate TWA estimation has a potential direct clinical impact on noninvasive SCD stratification, allowing better identification of patients at higher risk and helping clinicians in adopting the - ost appropriate therapeutic strategy.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
A new study finds that a psoriasis drug might help to reduce heart disease risk. Overall, it reduced a particular risk marker by 19 percent.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Heart Disease Source Type: news
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non–foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage function with respect to angiogenesis, vascular permeability, inflammation, and plaque progression. In human atherosclerotic lesions, CD163+ macrophages were ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionHere, we discuss the evidence for the use of PARPi as single-agent therapeutics and maintenance treatment in HGSOC and evaluate the genetic assays used in clinical trials so far. We discuss the emerging role of platinum sensitivity as a broad eligibility criteria for the use of PARPi.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Key Points Percutaneous PV implantation can be achieved in very small children (
Source: Catheterization and Cardiovascular Interventions - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Pediatric and Congenital Heart Disease Source Type: research
This study examined the effect of a DNA repair treatment on mitochondrial DNA (mtDNA) from aged and degraded skeletal samples. DNA extracts from 21 non-probative, degraded skeletal samples (aged 50–70 years) were utilized for the analysis. A portion of each sample extract was subjected to DNA repair using a commercial repair kit, the New England BioLabs’ NEBNext FFPE DNA Repair Kit (Ipswich, MA). MtDNA was enriched using PCR and targeted capture in a side-by-side experiment of untreated and repaired DNA. Sequencing was performed using both traditional (Sanger-type; STS) and next-generation sequencing (NGS) meth...
Source: Forensic Science International: Genetics - Category: Forensic Medicine Source Type: research
BackgroundSucralfate is a gastroprotectant with no known systemic effects. The efficacy of sucralfate for prevention and treatment of stress‐related mucosal diseases (SRMD) in dogs is unknown. Hypothesis/ObjectivesTo develop a canine ex vivo model of SRMD and to determine the effect of sucralfate on mucosal barrier function in this model. AnimalsGastric antral mucosa was collected immediately postmortem from 29 random‐source apparently healthy dogs euthanized at a local animal control facility. MethodsRandomized experimental trial. Sucralfate (100 mg/mL) was applied to ex vivo canine gastric mucosa concurrent with and ...
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: STANDARD ARTICLE Source Type: research
A cat was evaluated for an acute‐onset of right pelvic limb paresis. Thoracic radiographs revealed normal cardiac size and tortuous pulmonary arteries. Abdominal ultrasound identified a heartworm (HW) extending from the caudal abdominal aorta into the right external iliac artery and right femoral artery. The cat was HW‐antigen positive. Echocardiography revealed a HW within the right branch of the main pulmonary artery and evidence of pulmonary hypertension. An agitated‐saline contrast echocardiogram revealed a small right to left intracardiac shunt at the level of the atria. Surgical removal of the HW was performed ...
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: CASE REPORT Source Type: research
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