How does SGLT2 inhibition improve heart failure?

How does Sodium Glucose Cotransporter-2 (SGLT2) inhibition improve heart failure? Different ways by which SGLT2 inhibition can improve heart failure are: Natriuresis Osmotic diuresis These in turn leads to reduction of plasma volume and preload. An associated decrease in blood pressure, after load and arterial stiffness follows. Reduction in afterload can improve subendocardial blood flow as well. SGLT2 inhibitors are a new class of oral hypoglycemic agents. EMPA-REG OUTCOME trial with Empagliflozin (Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) and CANVAS trial (Canagliflozin Cardiovascular Assessment Study) are the two important studies which have demonstrated favorable cardiovascular effects with SGLT2 inhibitors. Reference Lytvyn Y et al. Sodium Glucose Cotransporter-2 Inhibition in Heart Failure. Potential Mechanisms, Clinical Applications, and Summary of Clinical Trials. Circulation. 2017;136:1643-1658.
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs