Space Invaders: Brain Tumor Exploitation of the Stem Cell Niche.

Space Invaders: Brain Tumor Exploitation of the Stem Cell Niche. Am J Pathol. 2017 Oct 09;: Authors: Sinnaeve J, Mobley BC, Ihrie RA Abstract Increasing evidence indicates that the adult neurogenic niche of the ventricular sub-ventricular zone (V-SVZ), beyond serving as a potential site of origin, affects the outcome of malignant brain cancers. Glioma contact with this niche predicts worse prognosis, suggesting a supportive role for the V-SVZ environment in tumor initiation or progression. In this review, we describe unique components of the V-SVZ that may permit or promote tumor growth within the region. Cell-cell interactions, soluble factors, and extracellular matrix composition are discussed, and the role of the niche in future therapies is explored. The purpose of this review is to highlight niche intrinsic factors that may promote or support malignant cell growth and maintenance, as well as point out how we might leverage these features to improve patient outcome. PMID: 29024634 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research