Lithium Treatment Aggregates the Adverse Effects on Erythrocytes Subjected to Arsenic Exposure.

Lithium Treatment Aggregates the Adverse Effects on Erythrocytes Subjected to Arsenic Exposure. Biol Trace Elem Res. 2017 Oct 07;: Authors: Bhardwaj P, Jain K, Dhawan DK Abstract The present study was designed to investigate the effects of lithium treatment on red blood cells which were given arsenic exposure. Long-term lithium therapy is being extensively used for the treatment of bipolar disorders. Arsenic is a group I carcinogen and a major toxic pollutant in drinking water that affects millions of people worldwide. Male SD rats were segregated into four groups, viz. normal control, lithium treated, arsenic treated, and lithium + arsenic treated. Lithium was supplemented as lithium carbonate at a dose level of 1.1 g/kg diet for a period of 8 weeks. Arsenic was given in the form of sodium arsenite at a dose level of 100 ppm in drinking water, ad libitum, for the same period. Lysates of red blood cells were used to investigate the effects of lithium and arsenic treatments on anti-oxidant enzymes, reduced glutathione (GSH), and lipid peroxidation (LPO) levels. Various hematological parameters, activities of Na(+) K(+) ATPase and delta-aminolevulinic acid dehydratase (δ-ALAD) were also assessed. A significant reduction was observed in the activities of antioxidant enzymes, GSH levels, total erythrocyte counts, Na(+) K(+) ATPase, and ALAD enzyme activities in lysates of red blood cells when exposed either to lithium or arsenic. In ...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research