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Protective effects of the caffeine against neurodegenerative diseases.

Protective effects of the caffeine against neurodegenerative diseases. Curr Med Chem. 2017 Oct 09;: Authors: Tellone E, Galtieri A, Russo A, Ficarra S Abstract Caffeine is one of the most consumed stimulant of the central nervous system. Similar to those of other stimulants, its effects are to improve brain activity and stimulate cognition learning and memory. Caffeine affects the brain by acting mainly as a non-selective blocker of the adenosine receptors (A1, A2A, A2B, and A3). The purpose of this review article is to provide an overview on the neurobiochemical impact of caffeine, focusing on the ability of the drug to effectively counteract several neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntington's diseases, Multiple sclerosis and Amyotrophic lateral sclerosis and Epilepsy. What emerges is a significant therapeutic and prophylactic potentiality of caffeine because of its antioxidant activity combined with multiple molecular targets. Moreover, it is striking to note that a molecule such as caffeine, appeared in the land plants few billion years ago may be an efficient drug for cells of more recent evolutionary origin. PMID: 28990513 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research

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Source: Health Reports - Category: International Medicine & Public Health Tags: Health Rep Source Type: research
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Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - Category: Molecular Biology Authors: Tags: Full Length Article Source Type: research
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Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
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Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
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Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research
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