Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial

AbstractSTUDY QUESTIONDoes an intensive weight reduction programme prior to IVF increase live birth rates for infertile obese women?SUMMARY ANSWERAn intensive weight reduction programme resulted in a large weight loss but did not substantially affect live birth rates in obese women scheduled for IVF.WHAT IS ALREADY KNOWNAmong obese women, fertility and obstetric outcomes are influenced negatively with increased risk of miscarriage and a higher risk of maternal and neonatal complications. A recent large randomized controlled trial found no effect of lifestyle intervention on live birth in infertile obese women.STUDY DESIGN, SIZE, DURATIONA prospective, multicentre, randomized controlled trial was performed between 2010 and 2016 in the Nordic countries. In total, 962 women were assessed for eligibility and 317 women were randomized. Computerized randomization with concealed allocation was performed in the proportions 1:1 to one of two groups: weight reduction intervention followed by IVF-treatment or IVF-treatment only. One cycle per patient was included.PARTICIPANTS/MATERIALS, SETTING, METHODSNine infertility clinics in Sweden, Denmark and Iceland participated. Women under 38 years of age planning IVF, and having a BMI ≥30 and<35 kg/m2 were randomized to two groups: an intervention group (160 patients) with weight reduction before IVF, starting with 12 weeks of a low calorie liquid formula diet (LCD) of 880 kcal/day and thereafter weight stabilization for 2 –5 weeks, or...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research