TLR9 is upregulated in human and murine NASH: pivotal role for inflammatory recruitment and cell survival.

Conclusion: Our novel clinical data and studies in over-nutrition models, including those with diabetes and metabolic syndrome, clarify TLR9 as a pro-inflammatory trigger in NASH. This response is mediated via M1-macrophages and neutrophil chemotaxis.

Source: Clinical Science - July 7, 2017 Category: Biomedical Science Authors: Mridha, A. R., Haczeyni, F., Yeh, M. M., Haigh, W. G., Ioannou, G. N., Barn, V., Ajamieh, H., Adams, L., Hamdorf, J. M., Teoh, N. C., Farrell, G. C. Tags: PublishAheadOfPrint Source Type: research