Do We Dare To Eat Lectins?

In The Love Song of J. Alfred Prufrock, T.S. Eliot’s protagonist asks, chewing on mortality and the pangs of senescence, if he dares to eat a peach. We can all thank Dr. Steven Gundry for upping the ante, and asking if any of us dares to eat chickpeas or eggplant; apples or oats; beans or lentils; or for that matter, almost any fruit, many vegetables, and most beans, legumes, grains, and certain nuts. His answer is: no. His reason is: lectins. What are lectins? I am tempted to suggest to all Harry Potter fans that they are to us muggles what Nargles are to witches and wizards: an enigmatic if not imaginary threat in unexpected places, of concern only to the eccentric. But I suppose a bit more explanation is in order. Lectins are a family of proteins found in many plants, dairy, yeast, eggs, and seafood that can bind to other molecules, notably sugar and carbohydrate molecules, that are present both in foods, and in the membranes of our cells. The case made in The Plant Paradox is that the binding of lectins from plant foods to our cells is a major cause of ill health, and thus we must all fear and avoid lectins, and the rather dire foods- like apples- that sinisterly serve as their delivery vehicles. (For whatever it may be worth to you and Prufrock, peaches happen to be a negligible source.) This, of course, is utter nonsense. For starters, the reality of lectins is far more nuanced than the sound bites, scapegoats, and silver bullets of f...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Authors: Zizzi CF, Pellicano R, Biancone L Abstract A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Beyond its role in the pathogenesis of the main gastroduodenal diseases, including gastritis, peptic ulcer and gastric cancer, H. pylori has been suspected to be involved in several extra-gastroduodenal disorders. Patients with chronic kidney disease (CKD) present gastric mucosal ...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells. Oncol Rep. 2020 Jul;44(1):371-381 Authors: Yoshida J, Ishikawa T, Endo Y, Matsumura S, Ota T, Mizushima K, Hirai Y, Oka K, Okayama T, Sakamoto N, Inoue K, Kamada K, Uchiyama K, Takagi T, Naito Y, Itoh Y Abstract Epithelial‑mesenchymal transition (EMT) is considered a crucial event in the development of cancer metastasis. Metformin is a drug used in the treatment of type 2 diabetes. Recently, increasing evidence has indicated that metformin possesses anti‑tumor activities. ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
ConclusionsOur retrospective analysis showed that metformin with front-line chemotherapy in diabetic patients resulted in improved PFS and OS. Our pre-clinical studies demonstrate metformin has potential to re-sensitize resistant lymphoma to the chemo-immunotherapy and allow us to develop a hypothesis as to its activity in DLBCL.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research
Contributors : Monta Ustinova ; Laura Ansone ; Ivars Silamikelis ; Vita Rovite ; Ilze Elbere ; Laila Silamikele ; Ineta Kalnina ; Davids Fridmanis ; Jelizaveta Sokolovska ; Ilze Konrade ; Valdis Pirags ; Janis KlovinsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the treatment of multiple health conditions, the glycemic response to metformin is highly variable, emphasizing the need for reliable biomarkers. We chose the RNA-Seq-bas...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Optimal health benefits from exercise are achieved by meeting both aerobic and muscle strengthening guidelines, however, most older adults (OAs) do not exercise and the majority of those who do only perform one type of exercise. A pragmatic solution to this problem may be emphasizing a single exercise strategy that maximizes health benefits. The loss of muscle mass and strength at an accelerated rate are hallmarks of aging that, without intervention, eventually lead to physical disability and loss of independence. Additionally, OAs are at risk of developing several chronic diseases. As such, participating in activities tha...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In recent years, the incidence of diabetes mellitus and cancer has increased sharply; indeed, these have become the two most important diseases threatening health and survival. Head and neck (HN) tumors are the sixth most common malignancies in humans. Numerous studies have shown that there are many common risk factors for diabetes mellitus and HN squamous cell carcinoma, including advanced age, poor diet and lifestyle, and environmental factors. However, the mechanism linking the two diseases has not been identified. A number of studies have shown that diabetes affects the development, metastasis, and prognosis of HN canc...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
This study aims to explore the efficacy of MET and MET combined with nitric oxide donor prodrug JS-K on the proliferation, apoptosis, and DNA damage in human renal cell carcinoma (RCC) cells, and investigate the possible molecular mechanism involved. The cell proliferation was tested through methyl-tetrazolium assay and cell apoptosis was ascertained by flow cytometry. The dihydroethidium and JC-1 fluorescent methods were used to detect Reactive oxygen species (ROS) and mitochondrial transmembrane potential (Δψm), respectively. Proteins associated with apoptosis and DNA damage were evaluated by Western blotting. ...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Abstract We aimed to fully review the association of empirical dietary patterns with the risk of noncommunicable chronic diseases and to rate the quality of the evidence. Published meta-analyses of observational studies investigating the association of empirically-derived dietary patterns with the risk of chronic diseases were identified by searching PubMed and Scopus till September, 2019. Two independent reviewers extracted the information and rated the quality of the evidence by NutriGrade score. For each meta-analysis, cross-sectional and case-control studies were excluded and then, summary relative risk (SRR) ...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
Conclusions Type 2 diabetes mellitus is associated with pNET metastasis and not an independent risk factor for poor prognosis in pNETs.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
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