ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage

ConclusionThe ELA-APJ axis protects from pressure overload-induced heart failure possibly via suppression of ACE expression and pathogenic angiotensin II signalling. The different effects of ELA and Apelin on the expression of ACE and ACE2 implicate fine-tuned mechanisms for a ligand-induced APJ activation and downstream signalling.
Source: Cardiovascular Research - Category: Cardiology Source Type: research