Clinical Implications for Germline PTEN Spectrum Disorders.

Clinical Implications for Germline PTEN Spectrum Disorders. Endocrinol Metab Clin North Am. 2017 Jun;46(2):503-517 Authors: Ngeow J, Sesock K, Eng C Abstract Patients with PTEN hamartoma tumor syndrome (PHTS) may present to a variety of different subspecialties with benign and malignant clinical features. They have increased lifetime risks of breast, endometrial, thyroid, renal, and colon cancers, as well as neurodevelopmental disorders such as autism spectrum disorder. Patients and affected family members can be offered gene-directed surveillance and management. Patients who are unaffected can be spared unnecessary investigations. With longitudinal follow-up, we are likely to identify other non-cancer manifestations associated with PHTS such as metabolic, immunologic, and neurologic features. PMID: 28476234 [PubMed - in process]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Endocrinol Metab Clin North Am Source Type: research