Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy [Arrhythmia and Electrophysiology]

ConclusionsThis DM mutant mouse model presented with clinical myofibril ultrastructural abnormality and cardiac arrhythmias, including atrial tachyarrhythmias, atrioventricular block, and ventricular tachyarrhythmias. Optical mapping studies revealed prolonged action potential duration and slow conduction velocity in the DM mice, leading to vulnerability of spatially discordant alternans and ventricular arrhythmia induction to pacing.

Source: JAHA:Journal of the American Heart Association - April 17, 2017 Category: Cardiology Authors: Chou, C.-C., Chang, P.-C., Wei, Y.-C., Lee, K.-Y. Tags: Arrhythmias, Basic Science Research Original Research Source Type: research