Sigma 1 Receptor and Ion Channel Dynamics in Cancer.

Sigma 1 Receptor and Ion Channel Dynamics in Cancer. Adv Exp Med Biol. 2017;964:63-77 Authors: Soriani O, Rapetti-Mauss R Abstract SigmaR1 is a multitasking chaperone protein which has mainly been studied in CNS physiological and pathophysiological processes such as pain, memory, neurodegenerative diseases (amyotrophic lateral sclerosis , Parkinson's and Alzheimer's diseases, retinal neurodegeneration ), stroke and addiction . Strikingly, G-protein and ion channels are the main client protein fami lies of this atypical chaperone and the recent advances that have been performed for the last 10 years demonstrate that SigmaR1 is principally activated following tissue injury and disease development to promote cell survival. In this chapter, we synthesize the data enhancing our comprehension of the interaction between SigmaR1 and ion channels and the unexpected consequences of such functional coupling in cancer development. We also describe a model in which the pro-survival functions of SigmaR1 observed in CNS pathologies are hijacked by cancer cells to shape their electrical signature and behavior in response to the tumor microenvironment . PMID: 28315265 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

Related Links:

Publication date: Available online 23 February 2019Source: Advances in Biological RegulationAuthor(s): Alice Domenichini, Jeanne S. Edmands, Aleksandra Adamska, Romana-Rea Begicevic, Silvano Paternoster, Marco FalascaAbstractCancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attract interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the characteristi...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: Available online 22 February 2019Source: Carbohydrate PolymersAuthor(s): Elham Gholibegloo, Tohid Mortezazadeh, Fatemeh Salehian, Ali Ramazani, Massoud Amanlou, Mehdi KhoobiAbstractA novel β-cyclodextrin-based nanosponge (CDNS) was proposed as curcumin (CUR) delivery system improving pharmacokinetics and anticancer activity of CUR. The effect of molar ratio of Epiclon (EPI) as cross-linker and β-cyclodextrin (βCD) on the porosity, surface area, swelling ratio, CUR solubility and loading capacity, rate of drug release and selective toxicity of the CDNSs was fully investigated. The high degre...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 22 February 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Mojtaba Falahati, Farnoosh Attar, Majid Sharifi, Thomas Haertlé, Jean-François Berret, Rizwan Hasan Khan, Ali Akbar SabouryAbstractNanoparticle (NP)–protein complexes exhibit the “correct identity” of NP in biological media. Therefore, protein–NP interactions should be closely explored to understand and to modulate the nature of NPs in medical implementations. This review focuses mainly on the physicochemical parameters such as dimension, surface chemistry, the mo...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Publication date: 15 May 2019Source: Sensors and Actuators B: Chemical, Volume 287Author(s): Yongfei Huang, Yongbin Zhang, Fangjun Huo, Jianbin Chao, Caixia YinAbstractThe reactive oxygen species (ROS) including hypochlorous acid (HOCl), on the one hand they can regulate physiological function in our living organisms, on the other hand abnormal concentration of ROS would induce a series of biomacromolecules damage and further endanger virtually all aspects of human health. Especially it can be directly related to cancer. Thus to elucidate and visualize their concentration is very imminent. Before many fluorescent probes we...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Chandra Shekhar Pundir, Mansi Malik, Reeti ChaudharyAbstractPyruvate (carboxylate anion of pyruvic acid) is an organic molecule, with a backbone of 3‑carbon atoms. Pyruvate is known to undergo several fates depending upon the organism under consideration. It is one of the only molecules involved in both synthesis and breakdown pathways, thereby making it a very busy molecule. Aberrant levels of this metabolite are known to cause several disorders like diabetes, cirrhosis, cardiovascular diseases and severe brain abnormalities. This is an attrac...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Abstract Although cigarette smoking is a major risk factor for lung cancer, genetic susceptibility may also affect lung cancer risk. To explore the role of genetic risk, this case-control study investigated the association between family history of cancer at several sites and lung cancer risk. A total of 1,733 lung cancer cases and 6,643 controls were selected from patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009. Information on family history of cancer was collected using a self-administered questionnaire and odds ratios (ORs) were estimated by unconditional logistic re...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
I’m 37 and I have incurable bowel cancer. It’s spread to my liver and lungs. I was diagnosed three years ago, I have just an 8% chance of being alive in 2021.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, a microdialysis-ultra-high-performance liquid chromatography-tandem mass spectrometry (MD-LC-MS/MS) method was designed for the simultaneous determination of active constituents in the rubber patch, such as paeonol (Pae), eugenol (Eug), and piperine (Pip). A microdialysis probe was implanted in the subcutaneous tissue of a rat, which is intended to detect the subcutaneous concentrations of target components. Saline containing 30% ethanol acted as perfusion fluid. Analytes in the microdialysate were completely separated over an ACQITY UPLC RBEH C18 column (2.1mm×100mm, 1.7μm). The mobile phase was co...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 23 February 2019Source: European UrologyAuthor(s): Renate Pichler, Isabel Heidegger
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsThe EAU Prostate Cancer Centre Consensus Meeting defined the criteria for the identification of the EPCCE in the fields of clinics, research, and education. The inclusion of a quality control approach represents the novelty that supports the excellence of these centres.Patient summaryA task force of experts defined the criteria for the identification of European Prostate Cancer Centres of Excellence, in order to certify the high-quality centres for prostate cancer management.
Source: European Urology - Category: Urology & Nephrology Source Type: research
More News: Addiction | ALS | Alzheimer's | Biology | Cancer | Cancer & Oncology | Neurology | Pain | Parkinson's Disease | Research | Sexual Abuse | Stroke