Michael J. Fox Foundation for Parkinson’s Research Alpha-Synuclein Pathology LEAPS Awards 2014

Michael J. Fox Foundation Alpha-Synuclein Pathology LEAPS Awards 2014 DEADLINES Informational Conference Call*: May 21, 2014 at 12pm US ET Pre-Proposals Due: June 16, 2014 no later than 6pm US ET Full Proposal Invitations: July 16, 2014 Full Proposals Due (by invite only): August 21, 2014 no later than 6pm US ET Anticipated Award Announcement: October 2014 Anticipated Funding: November 2014 *MJFF will hold a 45-minute conference call at the time listed above to clarify and explain the goals of this funding initiative and answer applicant questions.  To participate in the call and receive call-in details, please RSVP via email to conferencecalls@michaeljfox.org, listing “Asyn Pathology LEAPS 2014” in the subject of the email. BACKGROUND AND RATIONALE Mutations in the aSyn gene were some of the first genetic alterations linked to Parkinson's disease. The aSyn protein is also a major component of Lewy bodies, clumps of aggregated protein that are a cardinal neuropathological feature of Parkinson's disease. Accumulating evidence suggests that many species of aSyn protein exist in human tissues resulting from alternate splicing or post-translational modifications and that dysregulation of these species may lead to oligomerization and aggregation, events strongly associated with pathogenesis. These genetic and pathological links make aSyn a key target for therapeutic development. However, to effectively translate aSyn into the clinic, we...
Source: ScanGrants feed - Category: Research Authors: Source Type: funding

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A behavioral brain fad called “dopamine fasting” (#dopaminefasting) has been floating around the internet for the past year. The idea is that by restricting most of your pleasurable daily activities — from social media, to watching videos, gaming, talking, or even eating — you can “reset” your brain. The idea also plays into people’s simplistic beliefs about how the brain works. Can you have conscious control over discrete dopamine levels in your brain? Let’s delve into the science behind one of your brain’s most important neurotransmitters, dopamine. During a “d...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Mental Health and Wellness Motivation and Inspiration Psychology Research dopamine fasting Neuroscience Neurotransmitter social media Technology unplug Source Type: blogs
The brain is an energy-hungry organ, and is sensitive to reductions in the blood supply of oxygen and nutrients. Cardiovascular aging can reduce that supply, whether through conditions such as heart failure, or the progressive loss of density in capillary networks that occurs throughout the body with advancing age, or an accelerated pace of rupture of tiny vessels in the brain, or disruption of the blood-brain barrier, allowing unwanted molecules and cells to enter the brain. Thus, as researchers here note, we would expect to see correlations between cardiovascular disease, or risk factors for cardiovascular disease, and d...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In conclusion, the present study is the first to report the application of ddPCR in the pharmacokinetics profile description of tracking of hNSCs in preclinical studies. PMID: 31705124 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharmacol Sin Source Type: research
Publication date: Available online 1 November 2019Source: NeuroscienceAuthor(s): Hala El Khoury, John Mitrofanis, Luke A HendersonAbstractWe explore whether near infrared light can change patterns of resting (task-negative) and/or evoked (task-positive; eg finger-tapping) brain activity in normal, young human subjects using fMRI (functional magnetic resonance imaging). To this end, we used a vielight transcranial device (810nm) and compared the scans in subjects after active- and sham-light sessions. Our fMRI results showed that, while light had no effect on cerebral blood flow and global resting state brain activity (task...
Source: Neuroscience - Category: Neuroscience Source Type: research
Abstract Dopaminergic afferents innervate spiny projection neurons (SPNs) in the striatum, maintaining basal ganglia activity. The loss of striatal innervation is the hallmark of Parkinson's disease (PD), which is characterized by dopaminergic denervation. A lack of dopamine in the dorsal striatum induces plasticity changes in SPNs. However, PD-associated denervation is progressive, and how plasticity is modified in partially innervated areas is poorly understood. The most studied models of PD are based on the use of neurotoxins that induce an almost complete striatal denervation. To investigate the impact of part...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
AbstractBeta-amyloid (A β) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer’s disease (AD). However, the characteristics of Aβ brain networks in Parkinson’s disease (PD) are unknown. In the present study using positron emission tomography (PET) with [11C]-Pittsburgh compound B (PiB), we applied a graph theory –based analysis to assess the topological properties of Aβ brain network in PD patients with and without Aβ burden (PiB-positive ...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized HealthSummit19 technology Source Type: news
Conclusions: The PDICD(+) group has specific neuroanatomical variations in the nucleus accumbens and temporal lobes, which may contribute to the development of ICD and perhaps predispose a patient to ICDs on exposure to dopamine replacement therapy.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
ConclusionWM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.
Source: Neurological Sciences - Category: Neurology Source Type: research
Parkinson's disease is a heterogeneous disorder with both motor and non-motor symptoms that contribute to functional impairment. To develop effective, disease modifying treatments for these symptoms, biomarkers are necessary to detect neuropathological changes early in the disease course and monitor changes over time. Advances in MRI scan sequences and analytical techniques present numerous promising metrics to detect changes within the nigrostriatal system, implicated in the cardinal motor symptoms of the disease, and detect broader dysfunction involved in the non-motor symptoms, such as cognitive impairment.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
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