Michael J. Fox Foundation Michael J. Fox Foundation for Parkinson’s Research Alpha-Synuclein Pathology LEAPS Awards 2014

Michael J. Fox Foundation Alpha-Synuclein Pathology LEAPS Awards 2014 DEADLINES Informational Conference Call*: May 21, 2014 at 12pm US ET Pre-Proposals Due: June 16, 2014 no later than 6pm US ET Full Proposal Invitations: July 16, 2014 Full Proposals Due (by invite only): August 21, 2014 no later than 6pm US ET Anticipated Award Announcement: October 2014 Anticipated Funding: November 2014 *MJFF will hold a 45-minute conference call at the time listed above to clarify and explain the goals of this funding initiative and answer applicant questions.  To participate in the call and receive call-in details, please RSVP via email to conferencecalls@michaeljfox.org, listing “Asyn Pathology LEAPS 2014” in the subject of the email. BACKGROUND AND RATIONALE Mutations in the aSyn gene were some of the first genetic alterations linked to Parkinson's disease. The aSyn protein is also a major component of Lewy bodies, clumps of aggregated protein that are a cardinal neuropathological feature of Parkinson's disease. Accumulating evidence suggests that many species of aSyn protein exist in human tissues resulting from alternate splicing or post-translational modifications and that dysregulation of these species may lead to oligomerization and aggregation, events strongly associated with pathogenesis. These genetic and pathological links make aSyn a key target for therapeutic development. However, to effectively translate aSyn...
Source: ScanGrants feed - Category: Research Authors: Source Type: funding