Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause

In the late 1980s, several observational studies and meta-analyses suggested that hormone replacement therapy (HRT) was beneficial for prevention of osteoporosis, coronary heart disease, dementia and decreased all-cause mortality. In 1992, the American College of Physicians recommended HRT for prevention of coronary disease. In the late 1990s and early 2000s, several randomized trials in older women suggested coronary harm and that the risks, including breast cancer, outweighed any benefit. HRT stopped being prescribed at that time, even for women who had severe symptoms of menopause.

Source: Atherosclerosis - October 5, 2016 Category: Cardiology Authors: Roger A. Lobo, J.H. Pickar, J.C. Stevenson, W.J. Mack, H.N. Hodis Tags: Review article Source Type: research