Steroid treatments for arthritis 'may be possible with fewer side effects'

This study was mostly focused on application in the treatment of Addison's disease and congenital adrenal hyperplasia, but the researchers stated that with further development, it could lead to improved therapies for other conditions that respond to steroid treatment, includingrheumatoid arthritis and asthma. Dr Mark Nixon of the British Heart Foundation Centre for Cardiovascular Science at the University of Edinburgh said:"The discovery of this selective corticosterone pump in fat cells could lead to a completely new approach in our search for safer steroid medications." The Arthritis Research UK view Dr Natalie Carter, head of research liaison and evaluation at Arthritis Research UK, said:"This is a very interesting study that could have an impact on the treatment of those living with rheumatoid arthritis. Corticosteroids have been a cornerstone of managing the inflammation caused by this debilitating condition that affects more than 400,000 people in the UK. However, a small number of people do experience side effects including weight gain, thinning of the bones and indigestion. "We look forward to seeing future studies and any possible new treatments that would reduce the side effects that some people have to live with on a daily basis."
Source: Arthritis Research UK - Category: Rheumatology Source Type: news

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Authors: Campos-Borges HC, Sanz-González SM, Zanón-Moreno V, Millán Salvador JM, Pinazo-Duran MD PMID: 31629562 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
In this study, we assessed effects of LPZ on adipocyte differentiation and function by using 3T3-L1 preadipocytes and HFD-induced obesity mice as an in vitro and in vivo model, respectively.Main methodsOil red O staining and intracellular triacylglycerol content were used to determine lipid accumulation. Glucose uptake was performed to measure mature adipocyte function. Expression of adipocyte genes was determined by qRT-PCR and immunoblotting.Key findingsLPZ has dual effects on differentiation of 3T3-L1 cells. At low concentrations, LPZ enhanced adipocyte differentiation via induction of PPARγ and C/EBPα, two ...
Source: Life Sciences - Category: Biology Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
This article summarizes the milestones in the development of upadacitinib leading to this first approval for the treatment of rheumatoid arthritis.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in inflammatory cells, rather than Gq, thereby stimulating adenylate cyclase activity. cAMP is able to trigger various downstream pathways, mainly the canonical PKA pathway and the non-canonical cAMP-activated guanine nucleotide exchange factor (EPAC) pathway. Classically, the presence of VPACs has been confined to the plasma membrane; however, VPAC1 location has been described in the ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Regulated hemostasis, inflammation and innate immunity entail extensive interactions between platelets and neutrophils. Under physiological conditions, vascular inflammation offers a template for the establishment of effective intravascular immunity, with platelets providing neutrophils with an array of signals that increase their activation threshold, thus limiting collateral damage to tissues and promoting termination of the inflammatory response. By contrast, persistent systemic inflammation as observed in immune-mediated diseases, such as systemic vasculitides, systemic sclerosis, systemic lupus erythematosus or rheuma...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Diabetology International - Category: Endocrinology Source Type: research
Two UCLA professors, Dr. Denise Aberle and Dr. Carol Mangione, have been elected to the National Academy of Medicine, one of the highest honors in health and medicine.Aberle is a professor of radiology and bioengineering, and vice chair for research in the department of radiological sciences at theDavid Geffen School of Medicine at UCLA. Mangione is the Barbara A. Levey&Gerald S. Levey  Professor of Medicine and Public Health and chief of the division of general internal medicine and health services research. They were among 100 new members announced Oct. 21 during the academy’s annual meeting in Washington,...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: diabetes Out of Pocket Costs Voters for Cures Source Type: news
The latest crowdfunded research project undertaken by the SENS Research Foundation involves using the genetically engineered maximally modifiable mouse lineage in order to demonstrate the ability to copy a version of the ATP8 mitochondrial gene into the cell nucleus, a process known as allotopic expression, and thus prevent mutational damage to this gene from degrading mitochondrial function. This is a modest step on the road towards bringing this class of genetic engineering project to the point of readiness for commercial development, when a biotech startup company could be created to carry it forward. In just a f...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
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