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Spruce Biosciences Provides Corporate Update on Series A Venture Financing, Leadership Team and Lead Clinical Program
Clinical-stage, rare endocrine disease Company expands leadership team and advances lead candidate for congenital adrenal hyperplasia SAN FRANCISCO, Oct. 12, 2017 -- (Healthcare Sales & Marketing Network) -- Spruce Biosciences, a clinical-stage biotech... Biopharmaceuticals, Venture Capital, Personnel Spruce Biosciences, congenital adrenal hyperplasia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 12, 2017 Category: Pharmaceuticals Source Type: news

Study Probes Rare Adrenal Disorder Tied to Gender Ambiguity Study Probes Rare Adrenal Disorder Tied to Gender Ambiguity
This work provides"a detailed description of the genetics and of the clinical spectrum of [congenital adrenal hyperplasia due to] 11beta – hydroxylase deficiency, which is treatable," says the senior author.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 6, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Congenital adrenal hyperplasia
is a genetic condition affecting the adrenal glands and interfering with normal growth and development in boys and girls. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - January 19, 2017 Category: Consumer Health News Source Type: news

What are Potential Health Problems Associated with Polycystic Ovary Syndrome?
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - December 5, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Steroid treatments for arthritis 'may be possible with fewer side effects'
This study was mostly focused on application in the treatment of Addison's disease and congenital adrenal hyperplasia, but the researchers stated that with further development, it could lead to improved therapies for other conditions that respond to steroid treatment, includingrheumatoid arthritis and asthma. Dr Mark Nixon of the British Heart Foundation Centre for Cardiovascular Science at the University of Edinburgh said:"The discovery of this selective corticosterone pump in fat cells could lead to a completely new approach in our search for safer steroid medications." The Arthritis Research UK view Dr Nat...
Source: Arthritis Research UK - August 22, 2016 Category: Rheumatology Source Type: news

Millendo starts Phase II trial of ATR-101 to treat CAH
US-based Millendo Therapeutics has commenced the multicentre, single-blind, multiple dose Phase II clinical trial of its new oral drug candidate, ATR-101, to treat classic congenital adrenal hyperplasia (CAH). (Source: Drug Development Technology)
Source: Drug Development Technology - June 9, 2016 Category: Pharmaceuticals Source Type: news

What Causes Vomiting?
Discussion Regurgitation is a passive expulsion of ingested material out of the mouth. It is a normal part of digestion for ruminants such as cows and camels. Nausea is an unpleasant abdominal perception that the person may describe as feeling ill to the stomach, or feeling like he/she is going to vomit. Anorexia is frequently observed. Nausea is usually associated with decreased stomach activity and motility in the small intestine. Parasympathetic activity may be increased causing pale skin, sweating, hypersalivation and possible vasovagal syndrome (hypotension and bradycardia). Retching or dry heaves is when there are sp...
Source: PediatricEducation.org - May 2, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Alder BioPharmaceuticals Strengthens and Expands Leadership Team Supporting Advancement of ALD403 Toward Future Commercialization
Company Announces Four Key Hires in Legal, Commercial Strategy, Quality and Corporate Communications BOTHELL, Wash., Feb. 09, 2016 -- (Healthcare Sales & Marketing Network) -- Alder BioPharmaceuticals, Inc. (ALDR), a clinical-stage biopharmaceutical com... Biopharmaceuticals, PersonnelAlder Biopharmaceuticals, Cushing's disease, Congenital Adrenal Hyperplasia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 9, 2016 Category: Pharmaceuticals Source Type: news

Quantitation of Plasma Renin Activity in Plasma Using Liquid Chromatography & ndash;Tandem Mass Spectrometry (LC-MS/MS)
We describe a semi-automated and simple method for the accurate and precise measurement of PRA from 500 & mu;L of plasma (250 & mu;L if blank subtraction is omitted, as discussed) using a liquid chromatography and tandem mass spectrometry (LC-MS/MS) method for angiotensin I (AngI) in 96-well format. After a 3 h AngI generation step at 37 & deg;C in buffering conditions at pH 6, the reaction is quenched with 10 % formic acid containing AngI internal standard. Sample preparation then proceeds with offline solid phase extraction, two wash steps, and methanol elution followed by injection into the LC-MS/MS system. ...
Source: Springer protocols feed by Imaging/Radiology - January 7, 2016 Category: Radiology Source Type: news

Quantification of Dehydroepiandrosterone, 11-Deoxycortisol, 17-Hydroxyprogesterone, and Testosterone by Liquid Chromatography-Tandem Mass Spectrometry (LC/MS/MS)
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders due to enzymatic defects in the biosynthetic pathway of cortisol and/or aldosterone. The analysis of cortisol, 17-hydroxyprogesterone (OHPG), dehydroepiandrosterone (DHEA), 11-deoxycortisol, and testosterone is generally performed in the diagnosis and/or follow-up of CAH. Cortisol is generally analyzed by immunoassays whereas other hormones are preferably assayed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). A multiple reaction monitoring, positive mode atmospheric pressure chemical ionization, LC/MS/MS method is described for ...
Source: Springer protocols feed by Imaging/Radiology - November 27, 2015 Category: Radiology Source Type: news

Quantitation of Plasma Renin Activity in Plasma Using Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)
We describe a semi-automated and simple method for the accurate and precise measurement of PRA from 500 μL of plasma (250 μL if blank subtraction is omitted, as discussed) using a liquid chromatography and tandem mass spectrometry (LC-MS/MS) method for angiotensin I (AngI) in 96-well format. After a 3 h AngI generation step at 37 °C in buffering conditions at pH 6, the reaction is quenched with 10 % formic acid containing AngI internal standard. Sample preparation then proceeds with offline solid phase extraction, two wash steps, and methanol elution followed by injection into the LC-MS/MS system. Quantitation is...
Source: Springer protocols feed by Imaging/Radiology - November 27, 2015 Category: Radiology Source Type: news

Your NEJM Group Today: Congenital Adrenal Hyperplasia, Chronic Fatigue Syndrome, Ohio Primary Care Opportunities (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 16, 2015 Category: Primary Care Source Type: news

Obesity linked to adrenal disorder in teens may increase risk for cardiovascular disease
Adolescents and young adults with congenital adrenal hyperplasia (CAH) have significantly increased amounts of abdominal fat tissue, placing them at greater risk for harmful conditions linked to obesity, including cardiovascular disease (CVD), researchers note. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 10, 2015 Category: Science Source Type: news

Neurocrine suspends two planned trials of genetic disorder drug
(Reuters) - Biotechnology company Neurocrine Biosciences Inc said it had suspended two planned clinical trials of its experimental drug to treat a potentially life-threatening genetic disorder called congenital adrenal hyperplasia. (Source: Reuters: Health)
Source: Reuters: Health - June 8, 2015 Category: Consumer Health News Tags: healthNews Source Type: news

Noninvasive prenatal testing: Effective, safe, preferred by parents
(European Society of Human Genetics) UK researchers say that none-invasive prenatal testing is feasible, acceptable to parents, and could be introduced into the National Health Service. The same team also found that the technique was effective in the prenatal diagnosis of congenital adrenal hyperplasia, which exposes a female fetus to male hormones and can result in the development of masculinized external genitalia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 5, 2015 Category: Global & Universal Source Type: news

Changing Attitudes Spark Movement Against Intersex Surgeries For Infants & Children
CHICAGO (AP) — She was born to a young Chicago couple, named Jennifer, and grew into a beautiful long-lashed child with wavy dark hair, big brown eyes and a yearning, youthful desire to be just like all the other girls. Only she wasn't. Doctors first noticed her slightly enlarged genitals, and then discovered she had testes inside her abdomen and male chromosomes. And so began a series of surgeries to make things "right." Jennifer Pagonis was born intersex, an umbrella term for several conditions in which an infant's reproductive anatomy doesn't conform to standard definitions of male or female. The physic...
Source: Science - The Huffington Post - April 17, 2015 Category: Science Source Type: news

International Fund raising for Congenital Adrenal Hyperplasia (IFCAH) 2014 call for proposals
The International Fund raising for Congenital Adrenal Hyperplasia (IFCAH) hopes to contribute to the emergence of new therapeutics of the disease and of its complications. Together with ESPE (European Society for Pediatric Endocrinology) it launches its fourth call for proposals.   Academic groups working directly or indirectly on congenital adrenal hyperplasia are encouraged to submit a project, if the expected results could potentially help the knowledge of pathophysiology and allow better management of the disease. The deadline ...
Source: Society for Endocrinology - January 20, 2014 Category: Endocrinology Source Type: news

'Key Player' Not Needed to Make Testosterone
(MedPage Today) -- A protein believed to be essential for production of testosterone and other steroid hormones is not so essential after all, a discovery that may improve treatment of hypogonadism and congenital adrenal hyperplasia. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - November 14, 2013 Category: Endocrinology Source Type: news

Cortisol therapy still leaves kids obese (Medpage Today, 11 July 2013)
A UK study published in Clinical Endocrinology assesses rates of obesity and high blood pressure in children with congenital adrenal hyperplasia attending a single clinic. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 16, 2013 Category: Endocrinology Source Type: news

Cortisol Therapy Still Leaves Kids Obese (CME/CE)
(MedPage Today) -- Despite a reduction in steroid doses over the last decade, a sizeable proportion of children with congenital adrenal hyperplasia are still obese and hypertensive, researchers found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 11, 2013 Category: Cardiology Source Type: news

Quality of life, steroid use assessed in adults with CAH (Endocrine Today, 28 June 2013)
A new study from the Society's Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE) has found that patients with CAH have a negative perception of their quality of life. This is in relation to their weight and the dose and type of medication they take.  The research was published in the European Journal of Endocrinology. Full article (site registration may be required) CAH Adult Study Executive (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 1, 2013 Category: Endocrinology Source Type: news

Body fat, insulin may be key in adrenal disorder (Medpage Today, 13 June 2013)
Research by the Society for Endocrinology Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE) on health and quality of life outcomes relating to treatment regimen in adults with CAH is published in European Journal of Endocrinology and Clinical Endocrinology. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - June 17, 2013 Category: Endocrinology Source Type: news

Body Fat, Insulin May Be Key in Adrenal Disorder (CME/CE)
(MedPage Today) -- Quality of life in congenital adrenal hyperplasia varied significantly by patients' body fat and insulin resistance, suggesting weight loss might help improve physical and mental function, British investigators reported. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 13, 2013 Category: Cardiology Source Type: news

TARTs in CAH
Few studies on exist on the prevalence of testicular adrenal rest tumours (TARTs) in boys and adolescent males with congenital adrenal hyperplasia (CAH). Aycan and colleagues assessed the long-term treatment outcomes of this patient group in a cohort of sixty individuals. They found a TART prevalence of 18.3% from 4 years of age, which responded well to high-dose steroid treatment. They recommend ultrasound screening of CAH patients from a young age to prevent infertility in adulthood. Read the full article in Aycan and colleagues (2013) Clinical Endocrinology 78 667—672. DOI: 10.1111/cen.12033 (Source: Society for Endocrinology)
Source: Society for Endocrinology - May 8, 2013 Category: Endocrinology Source Type: news

Screening for CAH Will Save Girls' Lives, TooScreening for CAH Will Save Girls' Lives, Too
Screening of newborns for congenital adrenal hyperplasia will save more lives than previously thought because it also picks up females with the condition, new research shows. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 27, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Unique Study Highlights Importance Of Universal Newborn Screening For Lethal Genetic Disorder
Contrary to current belief, routine newborn screening improves the detection of the lethal form of congenital adrenal hyperplasia (CAH) in girls as well as boys, saving lives in both sexes, according to a unique study of CAH during the last 100 years published Online First in The Lancet Diabetes and Endocrinology. Babies are routinely screened for CAH in most developed countries, but this is not yet the case in all countries, including the UK and Australia... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 26, 2013 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

Transition in endocrinology
Two articles in the January issue of Clinical Endocrinology tackle the issue of transition care. Gleeson and colleagues, in their single-centre study, evaluated whether young people with congenital adrenal hyperplasia have been successfully transitioned from paediatric care to specialist adult services, finding that in half of cases were lost to follow-up on transfer to adult services. Downing and colleagues made a similar evaluation across a wider range of endocrine conditions, covering services from Manchester, Lancashire and South Cumbria. They found that a quarter of paediatric patients did not attend the Young Person&...
Source: Society for Endocrinology - January 11, 2013 Category: Endocrinology Source Type: news