Successful Therapy Reduction and Intensification for Childhood Acute Lymphoblastic Leukemia Based on Minimal Residual Disease Monitoring: Study ALL10 From the Dutch Childhood Oncology Group [Pediatric Oncology]

Conclusion
Chemotherapy was substantially reduced safely in one-quarter of children with ALL who were selected on the basis of undetectable MRD levels, without jeopardizing the survival rate. Outcomes of patients with intermediate and high levels of MRD improved with therapy intensification.

Source: Journal of Clinical Oncology - July 19, 2016 Category: Cancer & Oncology Authors: Pieters, de Groot-Kruseman, Van der Velden, Fiocco, van den Berg, de Bont, Egeler, Hoogerbrugge, Kaspers, Van der Schoot, De Haas, Van Dongen Tags: Acute Lymphoblastic Leukemia Pediatric Oncology Source Type: research