Growth hormone and colon neoplastic growth [Medical Sciences]

Growth hormone (GH) excess in acromegaly is associated with increased precancerous colon polyps and soft tissue adenomas, whereas short-stature humans harboring an inactivating GH receptor mutation do not develop cancer. We show that locally expressed colon GH is abundant in conditions predisposing to colon cancer and in colon adenocarcinoma-associated stromal...

Source: Proceedings of the National Academy of Sciences - June 6, 2016 Category: Science Authors: Chesnokova, V., Zonis, S., Zhou, C., Recouvreux, M. V., Ben-Shlomo, A., Araki, T., Barrett, R., Workman, M., Wawrowsky, K., Ljubimov, V. A., Uhart, M., Melmed, S. Tags: PNAS Plus Source Type: research