Depression blood test could lead to personalised treatments

Conclusion This study shows how a new blood test in development can help identify people with depression who are most and least likely to benefit from antidepressants. While promising, the test is far from perfect. For example, it missed 39-43% of non-responders, meaning these people would continue to receive standard antidepressant treatment that is unlikely to work for them. A large proportion of patients (22-38%) also fell into the "intermediate" group who were neither responders nor non-responders, so the test wasn't too useful here. This means there is a significant proportion of people with depression who would not necessarily benefit from this test. However, we shouldn't be overly negative. A significant proportion of people were identified correctly as responders and non-responders, which is a big step forward on what happens today. The study was based on less than 200 people with depression, far too few to conclude whether it works well in most people with depression. Larger studies involving many hundreds, perhaps thousands, of people will be needed to establish this, and is the natural next step for this research.   Links To The Headlines New blood test targets depression. BBC News, June 7 2016 Blood test could identify people who will respond to antidepressants. The Guardian, June 7 2016 Simple blood test could stop doctors using 'trial and error' to prescribe antidepressants, scientists claim. The Daily Telegraph, June 7 2...
Source: NHS News Feed - Category: Consumer Health News Tags: Mental health Medication Source Type: news

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This study explored the experience ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
ConclusionsThis study provides an initial insight into how fatigued adolescents with MDD experience CBT. Further research is required to establish whether the themes are pervasive and relatedly, how best to treat depression in fatigued adolescents receiving CBT.Practitioner points Fatigued adolescents with depression found engaging in CBT sessions and therapeutic homework demanding. Establishing a collaborative therapeutic relationship, where the therapist was perceived as genuine, appeared helpful for participation. The structured approach to therapy, combined with flexibility, was experienced as helpful. Adolescents w...
Source: Psychology and Psychotherapy: Theory, Research and Practice - Category: Psychiatry & Psychology Authors: Tags: Qualitative Paper Source Type: research
The talk therapy that is quicker (and cheaper) than cognitive-behavioural therapy.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Depression subscribers-only Source Type: blogs
DiscussionThe outcome of this trial will benefit health services in Canada, in terms of helping to reduce the burden of depression and anxiety and provide better care for South Asians. We expect the results to help guide the development of better services and tailor existing services to the needs of other vulnerable groups.Trial registrationClinicalTrials.gov NCT04010890. Registered on July 8, 2019
Source: Trials - Category: Research Source Type: clinical trials
Conclusions: Group-based CBTm classes, whether delivered in person or via telepsychology, appear to be an effective avenue for improving mental well-being and service access among rural community members. Although encouraging, results also suggested a need for research  on predictors of and reducing antecedents to class dropout in this population.
Source: Journal of Rational-Emotive and Cognitive-Behavior Therapy - Category: Psychiatry & Psychology Source Type: research
Nicola Walker, Madeleine Vernon-Smith, Michael Townend Mental Health Review Journal, Vol. ahead-of-print, No. ahead-of-print, pp.- No current psychotherapeutic intervention is designed to enhance job retention in employees with moderate–severe recurrent depression. The aim of this study is to test the feasibility of a new, interdisciplinary work-focused relational group cognitive behavioural therapy (CBT) treatment programme for moderate–severe depression. The programme was based on a theoretical integration of occupational stress, psychological, social/interpersonal and bio-medical theori...
Source: Mental Health Review Journal - Category: Psychiatry Authors: Source Type: research
ConclusionsThe intervention was feasible and highly acceptable to treatment completers. This suggests the intervention warrants investigation in a randomized-controlled trial.Practitioner points Young people with low self-esteem whom have been negatively affected by stigma may wish to access support and be willing to engage in psychological interventions. Cognitive behavioural therapy may be helpful for young people with low self-esteem who have experienced stigma, prejudice, or discrimination. Cognitive behavioural techniques such as self-compassionate thought records and behavioural experiments were considered accept...
Source: Psychology and Psychotherapy: Theory, Research and Practice - Category: Psychiatry & Psychology Authors: Tags: Original Article Source Type: research
INTRODUCTION: Cognitive behavioural therapy (CBT) is an established first-line treatment for depression; however, it remains unclear which factors predict a positive outcome with this approach. Prior work suggests that co-morbid obesity predicts a poorer r...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
AbstractSleep disorders are linked to development of type 2 diabetes and increase the risk of developing diabetes complications. Treating sleep disorders might therefore play an important role in the prevention of diabetes progression. However, the detection and treatment of sleep disorders are not part of standardised care for people with type 2 diabetes. To highlight the importance of sleep disorders in people with type 2 diabetes, we provide a review of the literature on the prevalence of sleep disorders in type 2 diabetes and the association between sleep disorders and health outcomes, such as glycaemic control, microv...
Source: Diabetologia - Category: Endocrinology Source Type: research
The Cochrane Common Mental Disorders Group has produced many reviews of the effects on interventions for conditions such as anxiety and depression. They added to these in November 2020 with a substantially revised version of their review of the use of cognitive behavioural therapy for children and adolescents. We asked one of the authors, Tessa Reardon from the University of Oxford in the UK, to tell us about the importance of this review and what it found.
Source: Podcasts from The Cochrane Library - Category: General Medicine Authors: Source Type: podcasts
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