Depression blood test could lead to personalised treatments

Conclusion This study shows how a new blood test in development can help identify people with depression who are most and least likely to benefit from antidepressants. While promising, the test is far from perfect. For example, it missed 39-43% of non-responders, meaning these people would continue to receive standard antidepressant treatment that is unlikely to work for them. A large proportion of patients (22-38%) also fell into the "intermediate" group who were neither responders nor non-responders, so the test wasn't too useful here. This means there is a significant proportion of people with depression who would not necessarily benefit from this test. However, we shouldn't be overly negative. A significant proportion of people were identified correctly as responders and non-responders, which is a big step forward on what happens today. The study was based on less than 200 people with depression, far too few to conclude whether it works well in most people with depression. Larger studies involving many hundreds, perhaps thousands, of people will be needed to establish this, and is the natural next step for this research.   Links To The Headlines New blood test targets depression. BBC News, June 7 2016 Blood test could identify people who will respond to antidepressants. The Guardian, June 7 2016 Simple blood test could stop doctors using 'trial and error' to prescribe antidepressants, scientists claim. The Daily Telegraph, June 7 2...
Source: NHS News Feed - Category: Consumer Health News Tags: Mental health Medication Source Type: news

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Abstract Cognitive behavioural therapy for insomnia is the recommended treatment for chronic insomnia. However, up to a quarter of patients dropout from cognitive behavioural therapy for insomnia programmes. Acceptance, mindfulness and values-based actions may constitute complementary therapeutic tools to cognitive behavioural therapy for insomnia. The current study sought to evaluate the efficacy of a remotely delivered programme combining the main components of cognitive behavioural therapy for insomnia (sleep restriction and stimulus control) with the third-wave cognitive behavioural therapy acceptance and comm...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Patients suffering from cancer must face the illness itself, but also a lot of adversity throughout it. Indeed, there are multiple effects and side effects of cancer and a notable side effect is depression. Depression can affect up to 40% of cancer patients.1 CBT is an empirically effective treatment for severe depression. Therefore, CBT could be effective to treat depression in advanced cancer.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conditions:   Mild Traumatic Brain Injury;   Internet-Delivered Cognitive Behavioural Therapy;   Depression;   Anxiety Intervention:   Behavioral: Internet-delivered Cognitive Behavioural Therapy(ICBT) Sponsor:   Lawson Health Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Patients' fatigue, physical functioning and social adjustment all significantly improved following cognitive behavioural therapy for chronic fatigue syndrome in a naturalistic outpatient setting. These findings support the growing evidence from previous randomised control trials and suggest that cognitive behavioural therapy could be an effective treatment in routine treatment settings. PMID: 32930040 [PubMed - as supplied by publisher]
Source: J R Soc Med AND (has... - Category: General Medicine Authors: Tags: J R Soc Med Source Type: research
How well does behavioural activation therapy work for depression in adults?  And what about the effects of this treatment on depression for adults with long‐term physical conditions? Two new Cochrane systematic reviews look at the available evidence.Depression is a common mental health problem. It can cause a persistent feeling of sadness and loss of interest in people, activities, and things that were once enjoyable. Treatments for depression include psychological therapies (talking therapies). Two reviews recently published byCochrane Common Mental Disordersfocus on a type of psychological therapy called behaviour...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
INTRODUCTION: The traumatic death of a loved one, such as death due to a traffic accident, can precipitate persistent complex bereavement disorder (PCBD) and comorbid post-traumatic stress disorder (PTSD) and depression. Waitlist-controlled trials have sho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
CONCLUSIONS: Gaps exist in the evidence on mental health interventions for refugees, asylum seekers, and internally displaced persons. Most reviews do not specify that internally displaced persons are included in the selection criteria, even though they make up the majority of involuntary migrants worldwide. Reviews specific to mental health promotion and prevention of common mental disorders are missing, and there is more evidence available for adults or mixed populations than for children. The literature is focused on post-traumatic stress disorder and trauma-related symptoms, with less attention for depression and anxie...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Conclusions: WAI-TECH-SF is a reliable questionnaire to assess the TA between the patient and the online program, which is associated with positive therapeutic outcomes and satisfaction with the treatment.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionsOur findings give insufficient evidence to support a recommendation of either transdiagnostic or diagnosis-specific CBT for a given patient or to predict the response to the applied group therapies.
Source: Cognitive Therapy and Research - Category: Psychiatry & Psychology Source Type: research
We examined the effects of a fully-automated digital cognitive behavioural therapy intervention for insomnia (Sleepio) on insomnia and depressive symptoms, and the mediating role of sleep improvement on depressive symptoms in participants from two randomized controlled trials of digital cognitive behavioural therapy for insomnia. We also explored potential moderators of intervention effects. All participants met criteria for probable insomnia disorder and had clinically significant depressive symptomatology (PHQ-9 ≥ 10; n = 3,352). Individuals allocated to treatment in both trials were provided acces...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
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