Physiological Roles of Ubiquitin Ligases Related to the Endoplasmic Reticulum.

In conclusion, oxidative stress-induced HRD1 insolubilization might be involved in a vicious cycle of increased Aβ production and Aβ-induced oxidative stress in Alzheimer's disease pathogenesis.
PMID: 27252059 [PubMed - in process]

Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kaneko M Tags: Yakugaku Zasshi Source Type: research