Fungal infection of cystic fibrosis patients - single center experience.

CONCLUSIONS: A. fumigatus and C. albicans were the most common etiological agents of fungal respiratory pathogens associated with CF patients. A. fumigatus strains were in vitro 100% susceptible to azole and amphotericin B. Two strains of C. albicans and one strain of C. tropicalis were non-susceptible to azole (fluconazole, itraconazole and voriconazole). Scedosporium apiospermum was resistant to amphotericin B (MIC> 32 mg/l) and susceptible to voriconazole (MIC 0.094 mg/l). PMID: 27238177 [PubMed - in process]
Source: Pneumonologia i Alergologia Polska - Category: Respiratory Medicine Authors: Tags: Pneumonol Alergol Pol Source Type: research

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Publication date: Available online 15 January 2020Source: Protein Expression and PurificationAuthor(s): Uriel Rojas-Sánchez, Alberto Cristian López-Calleja, Blanca E. Millán-Chiu, Francisco Fernández, Achim M. Loske, Miguel A. Gómez-LimAbstractAspergillus niger has been employed to produce heterologous proteins due to its high capacity for expression and secretion; nevertheless, expression levels of human proteins have been modest. We were interested in investigating whether A. niger can express and secret human erythropoietin (HuEPO) at high yields. Our strategy was to combine the presen...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Conclusion: The combined picture of 'low IPT initiation and high completion' seen in our study mirrors findings from other countries. Drug stock-out was the key challenge, which obliged health-care providers to prioritize 'IPT completion' over 'IPT initiation'. There is an urgent need to improve the procurement and supply chain management of isoniazid. PMID: 31937200 [PubMed - in process]
Source: Global Health Action - Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
Contributors : Siyuan Feng ; Guobao TianSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mycolicibacterium smegmatis MC2 155To understand how GreA may affect gene expression at the transcriptional level, we performed whole-transcriptome RNA-seq analyses.To examine whether GreA binds to specific chromosomal regions, we performed chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) and then sought to verify the binding mode of GreA. ChIP-seq experiments were performed by using M. smegmatis strains producing GreA prote...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mycolicibacterium smegmatis MC2 155 Source Type: research
This study aimed to evaluate the efficacy of excimer laser (308 nm) as an alternative therapy for PV.MATERIALS AND METHODS: This is a prospective intra-patient left-to-right, randomized, placebo-controlled study conducted on 26 patients with bilateral lesions which are not responding to the PV standard treatment. Patients were randomly assigned to right or left-side therapy for a duration of 8 weeks with either excimer laser (308 nm three times weekly) or topical placebo. Clinical assessment and mycological evaluation were performed before the initiation of treatment and at the 4th and 8th week of therapy.RES...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
More than three years after being passed in the legislature, a new law that governs public health in Nunavut is in effect. 
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/North Source Type: news
-- Athlete's foot is a fungal infection that often occurs in people who wear damp socks or tight shoes, says Mayo Clinic. The infection is contagious and is spread by contact with an infected person or contaminated surfaces. To help prevent...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
We present an alternative, societal framework for economic evaluations that encompasses a broader set of socioeconomic benefits in addition to health benefits. Quantifying a more comprehensive taxonomy of PCV’s benefits will help to address potential undervaluation and may be sufficient not only to justify recommendation and reimbursement but also to stimulate efforts and investment toward closing coverage gaps.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Commentary Source Type: research
We investigated the impact of baseline tuberculin skin tests (TSTs) and preventive isoniazid chemoprophylaxis on subsequent QuantiFERON-TB Gold In-Tube (QFT-GIT) assays performed after a 10- to 12-week window period in 114 children
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
In this study, we reviewed in-vitro and in-vivo studies, as well as clinical reports pertaining to the antifungal efficacy of statins. In addition, we have addressed various modulators of statin anti-fungal activity and the potential mechanisms responsible for their anti-fungal effects. In general, statins do possess anti-fungal activity, targeting a broad spectrum of fungal organisms including human opportunistic pathogens such as Candida spp. and Zygomycetes, Dermatophytes, alimentary toxigenic species such as Aspergillus spp., and fungi found in device implants such as Saccharomyces cerevisiae. Statins have been shown t...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Contributors : Ningning Song ; Guanghui Dang ; Ziyin Cui ; Huajun Zheng ; Siguo LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosis variant bovisVitamins are organic compounds and essential nutrients required by host organism. Recent studies have shown that vitamin B1(VB1) and vitamin C (Vc) could inhibit Mycobacterium tuberculosis growth. However, the precise role of VB1 and Vc in M.tuberculosis are still not well understand. Therefore, in this study, the transcriptional, metabolic and methylation profiles of VB1 and VC treated Mycobacterium. bovis BCG were analyzed by ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mycobacterium tuberculosis variant bovis Source Type: research
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