A salute to Noah’s heroes

Noah Hamm has escaped death more times than his mother Danielle can count. And he’s only 3. Since Noah was born there have been three constants in his life: Noah’s knack for near misses, his family and a neonatologist/pulmonologist who’s always there with the right care for Noah … and the right words for his family. “I tell Larry [Dr. Larry Rhein] he’s our George Bailey,” says Noah’s mom Danielle DiBenedetto. Larry gave me hope. Even when things were bad, I always felt better when Larry was there. Noah was a 29-week twin when Danielle’s water broke prematurely. “The only condition I thought I had to worry about after having a STAT C-section was prematurity,” she recalls. Six hours after Noah and his sister Dakotah were born at Brigham and Women’s Hospital, specialists told Danielle and her husband Brendan their newborn son needed surgery for esophageal atresia, a gap in his esophagus, and tracheoesophageal fistula, an abnormal connection between his esophagus and trachea. Nurses brought Noah to Danielle to let her hold her son before transferring him to Boston Children’s Hospital. “They weren’t sure he’d make it through the first night,” says Danielle. But Noah did make it through the night and through his first surgery, when Dr. Terry Buchmiller, a surgeon at Boston Children’s, repaired Noah’s tracheaesophageal fistula and placed a G-tube to deliver nutriti...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories Dr. Anne Hansen Dr. Larry Rhein Dr. Reza Rahbar Dr. Terry Buchmiller esophageal atresia laryngeal cleft patent ductus arteriosus tracheoesophageal fistula Source Type: news

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CONCLUSIONS V-MSCs enhance homing and modulating immune balance in the experimental colitis, suggesting that they are potentially useful for treating inflammatory bowel disease or other immune diseases. PMID: 31201771 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Using 3D-printed models based on chest CT scans allows clinicians to personalize...Read more on AuntMinnie.comRelated Reading: AR, 3D printing enhance planning for complex heart surgery Radiologists rally in support of medical 3D printing AR, 3D printing aid presurgical planning for kidney cancer 3D printing reduces liver transplant costs, surgery time 3D printing boosts efficiency of rib fracture repair
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 15 June 2019Source: The Annals of Thoracic SurgeryAuthor(s): Johanna J.M. Takkenberg
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 15 June 2019Source: The Annals of Thoracic SurgeryAuthor(s): Pouya Youssefi, Pavel Zacek, Mathieu Debauchez, Emmanuel Lansac
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractPurpose of reviewThe purpose of this review was to evaluate the complexities and challenges associated with transcatheter mitral valve replacement and review the existing data.Recent findingsMany patients with mitral valve disease are not candidates for cardiac surgery and are in need of less invasive transcatheter therapies. The first transcatheter mitral valve replacement (TMVR) in a native valve was performed in 2012. However, the complexities and variability of the mitral valve anatomy and its relationship to neighboring structures have resulted in slower progress with this new therapy compared to the rapid upt...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
ConclusionWhen facing a case of aortic valve stenosis, accessory mitral valve tissue should be kept in mind as one of the possible underlying causes despite its rarity. Although it is simple and noninvasive, echocardiography remains the best diagnostic procedure to make the correct decision about management and to define the golden time for surgical intervention.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Bronchioalveolar stem cells (BASCs) are a potential source for lung regeneration, but direct in vivo evidence for a multipotential lineage contribution during homeostasis and disease is critically missing, since specific genetic labeling of BASCs has not been possible. We developed a novel cell tracing approach based on intein-mediated assembly of newly engineered split-effectors, allowing selective targeting of dual-marker expressing BASCs in the mouse lung. RNA sequencing of isolated BASCs demonstrates that BASCs show a distinct transcriptional profile, characterized by co-expression of bronchiolar and alveolar epit...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Development & Differentiation, Immunology, Stem Cells Articles Source Type: research
Lung epithelial progenitor cell populations fulfill the needs of this complex facultative regenerative organ when exposed to insult and contribute to repair in either the airway or alveolar compartments. The presence of a cell that can populate both epithelia had been proposed previously but has remained elusive. In this issue, Salwig et al (2019) provide compelling, genetic evidence that supports a growing narrative—a rare population of bronchioalveolar stem cells (BASCs) that can contribute to both airway and alveolar epithelium in the distal murine lung.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Development & Differentiation, Immunology, Stem Cells News [amp ] Views Source Type: research
AbstractMucopolysaccharidoses (MPS) are inborn errors of metabolism produced by a deficiency of one of the enzymes involved in the degradation of glycosaminoglycans (GAGs). Although taken separately, each type is rare. As a group, MPS are relatively frequent, with an overall estimated incidence of around 1 in 20,000 –25,000 births. Development of therapeutic options for MPS, including hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT), has modified the natural history of many MPS types. In spite of the improvement in some tissues and organs, significant challenges remain unsol ved, in...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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