Maintenance of Influenza Surveillance Capacity by National Health Authorities Outside the United States.

Funding Opportunity Number: CDC-RFA-IP16-1605 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.318Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: HHS-CDC-NCIRDClosing Date: Jul 18, 2016Award Ceiling: $0Expected Number of Awards: 27Creation Date: May 18, 2016Funding Opportunity Description: During the past decade, the U.S. Centers of Disease Control and Prevention (CDC) has worked with nations around the world to build capacity to prepare, detect, and respond to pandemics, both actual and potential. Through previous Funding Opportunity Announcements (FOA) and subsequent Cooperative Agreements, the CDC with international partners and national ministries of health focused on three pillars: 1) preparedness and communication; 2) surveillance and detection; 3) response and containment.The intent of this program is to provide additional support for countries that began and/or enhanced influenza surveillance networks and the systematic collection of virological and epidemiological influenza information with funding from the prior announcements or programs. Countries are expected to develop and implement detailed plans to fully assume responsibilities and funding for robust and timely routine surveillance systems for seasonal, novel and pandemic influenza. The systems should have the ability for rapid ...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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CONCLUSIONS: The LIPS method could differentiate between sera from experimentally infected and vaccinated animals. However, in human samples obtained more than 6 months after the pandemic, LIPS was specific, but not sufficiently sensitive for ascertaining cases by exposure. PMID: 31955522 [PubMed - as supplied by publisher]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Influenza Other Respir Viruses Source Type: research
AbstractPrevious studies of fetal death with maternal influenza have been inconsistent. We explored the effect of maternal influenza-like illness (ILI) in pregnancy on the risk of fetal death, distinguishing between diagnoses during regular influenza seasons and the 2009/2010 pandemic and between trimesters of ILI. We used birth records from the Medical Birth Registry of Norway to identify fetal deaths after the first trimester in singleton pregnancies (2006 –2013). The Norwegian Directorate of Health provided dates of clinical influenza diagnoses by primary-health-care providers, whereas dates of laboratory-confirme...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
In this study, single and multiple mutation were introduced to amino acid at position 148, 150 (site I) and 183, 186, 188 (site II) on the full-length HA gene of H9N2 strain (A/Hong Kong/33982/2009). These mutant HA constructs were displayed on the baculovirus surface (BacH9), and evaluated for their cross-protective efficacy against H9N2 viruses in a mouse model. Our findings indicate that mice immunized with multiple BacH9 mutant constructs (148-150 183 and 186) induced cross-protective immunity against circulating H9N2 in the viral challenge study and prove to be a promising vaccine candidate for H9N2. PMID: 319244...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Publication date: Available online 31 December 2019Source: Veterinary MicrobiologyAuthor(s): Dieudonné Tialla, Aurélie Sausy, Assana Cissé, Tani Sagna, Abdoul Kader Ilboudo, Georges Anicet Ouédraogo, Judith M. Hübschen, Zékiba Tarnagda, Chantal J. SnoeckAbstractDespite improvement of human and avian influenza surveillance, swine influenza surveillance in sub-Saharan Africa is scarce and pandemic preparedness is still deemed inadequate, including in Burkina Faso. This cross-sectional study therefore aimed to investigate the (past) exposure of pigs to influenza A viruses. Practices of ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
AbstractPatients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The entire Norwegian population in the years 2008 –2014 was defined as our study population (N = 5,219,296). Information on MS diagnosis, influenza infection and vaccination were provided by Norwegian...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
In this study, we comprehensively evaluated infectivity and transmissibility in Chinese tree shrews by using pandemic H1N1 (A/Sichuan/1/2009, pdmH1N1), avian-origin H5N1 (A/Chicken/Gansu/2/2012, H5N1) and early human-origin H7N9 (A/Suzhou/SZ19/2014, H7N9) IAVs. We found that these viruses replicated efficiently in primary tree shrew cells and tree shrews without prior adaption. Pathological lesions in the lungs of the infected tree shrews were severe on day 3 post-inoculation, although clinic symptoms were self-limiting. The pdmH1N1 and H7N9 viruses, but not the H5N1 virus, transmitted among tree shrews by direct contact. ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Seasonal and pandemic influenza infection remains a major public health concern worldwide. Driving robust humoral immunity has been a challenge given preexisting, often cross-reactive, immunity and in particular, poorly immunogenic avian antigens. To overcome immune barriers, the adjuvant MF59 has been used in seasonal influenza vaccines to increase antibody titers and improve neutralizing activity, translating to a moderate increase in protection in vulnerable populations. However, its effects on stimulating antibody effector functions, including NK cell activation, monocyte phagocytosis, and complement activity, all of w...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Notice NOT-AI-20-017 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A. We developed a novel anti-influenza A virus approach based on an engineered single-domain antibody (VHH) construct that can selectively recruit innate immune cells to the sites of virus replication. This protective construct comprises two VHHs. One VHH binds with nanomolar affinity to the conserved influenza A matrix protein 2 (M2) ectodomain (M2e). Co-crystal structure analysis revealed that the com...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Rebmann T, Charney RL, Loux TM, Turner JA, Abbyad YS, Silvestros M Abstract Objective Identify determinants of emergency medical service (EMS) personnel's willingness to work during an influenza pandemic.Background Little is known about the willingness of EMS personnel to work during a future influenza pandemic or the extent to which they are receiving pandemic training.Methods EMS personnel were surveyed in July 2018 - Feb 2019 using a cross-sectional approach; the survey was available both electronically and on paper. Participants were provided a pandemic scenario and asked about their willingness to res...
Source: Prehospital Emergency Care - Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
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