Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?

Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? World J Gastroenterol. 2016 Mar 14;22(10):2869-74 Authors: García-Compeán D, González-González JA, Lavalle-González FJ, González-Moreno EI, Villarreal-Pérez JZ, Maldonado-Garza HJ Abstract Diabetes mellitus (DM) that occurs because of chronic liver disease (CLD) is known as hepatogenous diabetes (HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus (HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, ...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

Related Links:

ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Publication date: Available online 17 February 2020Source: Journal of Forensic and Legal MedicineAuthor(s): Roger W. ByardAbstractIn previous years individuals with tattoos were thought to have a higher rate of mental illness and risk taking behaviour. With the widespread adoption of tattoos in Western countries in recent years this negative association has been questioned. An issue which arises, however, is that “tattooing” is a heterogeneous activity that covers a wide spectrum of designs and motivations. To examine the characteristics of individuals presenting to medicolegal autopsy with “expletive tat...
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02762A, PaperXirong Zheng, Xiabin Chen, Ting Zhang, Max Zhan, Chang-Guo Zhan, Fang Zheng Majority of cocaine users also consume alcohol. Concurrent use of cocaine and alcohol produces pharmacologically active metabolites cocaethylene and norcocaethylene, in addition to norcocaine. Both cocaethylene and norcocaethylene are more... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02760B, Review ArticleBhaskar Paul, Milan Maji, Kaushik Chakrabarti, Sabuj Kundu Construction of new C-C, C-N and C-O bonds by replacing hazardous and waste generating chemicals, with alcohols as the greener and sustainable reagents is one of the emerging area of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
ConclusionsTransplanting kidneys from HCV-viremic donors into HCV-uninfected recipients increased quality-adjusted life expectancy and reduced costs compared with a strategy of transplanting kidneys from HCV-unexposed donors.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Collaborative knowledge generation and involvement of users is known to improve health promotion intervention development, but research about the roles and perspectives of users in the co-creation process is sparse. This research aimed to study how young p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND AND OBJECTIVES: Young adults with childhood maltreatment (CM) histories are particularly vulnerable to depressive symptoms and alcohol use problems. Research suggests that maltreated youth may misuse alcohol in part to alleviate depressive sympt...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Patterns and correlates of substance use among urban African American young women (ages 18-19, n  = 459) were examined. Four patterns were identified: no/infrequent alcohol and marijuana use (64.9%); recent alcohol only use (18.2%); recent mariju...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Kratom or Mitragna speciosa is a tropical tree that is indigenous to Southeast Asia, where it has been used for various medicinal reasons. In the West, it is used in the self-treatment of opioid withdrawal, pain, and a variety of mood and anxiety states. T...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
More News: Alcoholism | Cancer & Oncology | Carcinoma | Cirrhosis | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Gastroenterology | Genetics | Hepatitis | Hepatitis C | Hepatocellular Carcinoma | Liver | Liver Cancer | Liver Disease | Pancreas | Pancreatic Cancer | Urology & Nephrology | Virology