Cardiac Assessment of Global Longitudinal Strain May Predict Early Mortality in Myeloma Patients Undergoing Melphalan ASCT

Patients undergoing high-dose melphalan followed by autologous stem cell transplant (Mel + ASCT) for multiple myeloma (MM) are subject to significant risk including fluid and electrolyte shifts and organ toxicity, particularly when there is pre-existing cardiovascular disease. Moreover, patients with MM have a 12-15% risk of developing clinical cardiac amyloidosis (CAL). It is not known whether subclinical CAL will affect outcomes in these patients. Echocardiography is the gold standard for the diagnosis of CAL with global longitudinal strain (GLS) and segmental longitudinal strain (SLS) as biomarkers for infiltrative cardiomyopathy.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Session C: Autologous Transplants, Lymphoma and Myeloma Source Type: research