Rituximab for the treatment of connective tissue disease-associated interstitial lung disease.

CONCLUSION: In this small, retrospective study of chronic CTD-ILD, RTX was not associated with changes in FVC% or corticosteroid-sparing effects. Controlled, prospective studies are needed to more confidently define the effects of RTX in CTD-ILD. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 296-304). PMID: 26847096 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

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Publication date: Available online 21 March 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Tong Tong, Zhihui Liu, Hua Zhang, Jinglei Sun, Dongxia Zhang, Feng Wang, Dechao Miao, Yong ShenAbstractAccumulating evidence shows that genetic polymorphism of the vitamin D receptor (VDR) gene is associated with intervertebral disc degeneration (IDD), implying that VDR may be involved in the pathogenesis of IDD. However, the exact relationship between VDR and IDD remains unknown. The aim of this study was to investigate the age-dependent expression of VDR in rat intervertebral discs and to determine ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 21 March 2019Source: The Journal of Supercritical FluidsAuthor(s): Diego Márlon Ferro, Simone Mazzutti, Luciano Vitali, Carmen Maria Oliveira Müller, Sandra Regina Salvador FerreiraAbstractIntegrated downstream processes, combining Supercritical Fluid Extraction (SFE) with Pressurized Liquid Extraction (PLE), were used to recover antioxidants from Sida rhombifolia leaves. The SFE depressurization step was evaluated to improve PLE efficiency in the recovery of phenolic compounds. Total phenolic content of the extracts was performed by Folin-Ciocalteu method, and in vitro antiox...
Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
Publication date: Available online 20 March 2019Source: Thermochimica ActaAuthor(s): Bruno B.C. Holanda, Gilbert Bannach, M. Ramos Silva, M. Ermelinda S. Eusébio, Ricardo A.E. CastroAbstractThe knowledge of polymorphism of active pharmaceutical ingredient is relevant in the pharmaceutical field. In this work, a multidisciplinary approach involving differential scanning calorimetry, polarized light thermal microscopy, X-ray powder diffraction and attenuated total reflectance infrared spectroscopy was used to investigate polymorphism of gemfibrozil (GEM), an important fibric acid derivative, in melting cooling/heating...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: June 2019Source: Microchemical Journal, Volume 147Author(s): Ademar Wong, Anderson Martin Santos, Elson Luiz Fava, Orlando Fatibello-Filho, Maria Del Pilar Taboada SotomayorAbstractA screen-printed disposable electrode made of carbon ink modified with CuPc, P6LC and Nafion film is proposed as a low-cost and simple analytical method for sensitive determination of 17β-estradiol in different matrices. The electrochemical behaviour of 17β-estradiol was evaluated by cyclic voltammetry in the potential range from 0 to 0.55 V at a scan rate of 0.05 V s−1 using 0.1 mol L−1 phosphat...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 March 2019Source: Journal of Solid State ChemistryAuthor(s): Zhang Hao, Li Lei, Wenbin WangAbstractNucleation and growth of ettringite in solution with and without temperature rising inhibitor (TRI) were investigated. Electrical conductivity, X-ray diffraction, scanning electron microcopy, optical microcopy and Fourier transform infrared were used to analyze the mechanism of effects of TRI on nucleation and growth of ettringite. Based on classical nucleation theory, the results show that TRI has little influence on the crystal-solution interfacial energy. In contrast, the inhibition of...
Source: Journal of Solid State Chemistry - Category: Chemistry Source Type: research
In this study, free-standing laminar GO membrane was obtained on the tip of glass nanopipette by electrophoresis. Scanning electron microscope (SEM), optimal microscope and electrochemical method were used to determine the assembly process, respectively. Stable and obvious rectification change shows that gas molecule can modulate ion migration owing to the change of charge density between GO sheets. Such results may pave the way for development of gas differentiation membrane, and study on fundamental mechanism.Graphical abstract
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
In this report, non-hydrogen bonded, segmented polyurethane (SPU) of ferrocene functionalized polybutadiene diol has been synthesized and studied in depth to understand the role of ferrocene moiety in the structure-property relationship of SPU. Interactions among hard segments of SPU through the ferrocene moiety played a vital role in the separation of hard and soft segments. Ferrocene attached hydroxyl terminated polybutadiene (HTPB) diol was polymerized with isophorone diisocyanate followed by curing at 70 °C to obtain polyurethane (PU). Dynamic mechanical analysis (DMA) and an in-depth small angle X-ray scattering (...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 22 March 2019Source: European Polymer JournalAuthor(s): Qian Zou, Fangli Hou, Hong Wang, Yonggui Liao, Qin Wang, Yajiang YangAbstractMultifunctional alginate microspheres encapsulated with in situ-formed bismuth sulfide nanoparticles (denoted as Bi2S3@BCA) were developed in this work. In comparison with conventional hybrid polymer microspheres usually involved in complicate preparation process, Bi2S3@BCA microspheres can be easily one-step prepared using a droplet-based microfluidic technique with alginate as a soft template and microspheric matrix. As-prepared Bi2S3@BCA microspheres has ...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Abstract Collagen membranes have been widely applied for guided bone regeneration (GBR), a technique often utilized in dental implant surgery for bone argumentation. However, the implantation of collagen membranes also elicits foreign body reaction (FBR), the imbalance of which may lead to failures of dental implants. Macrophages play a pivotal role in FBR as macrophages can polarize into pro-inflammatory (M1) and pro-regenerative (M2) phenotypes. Therefore, collagen membranes based on modulation of macrophage polarization have gained increased attention. Epigallocatechin-3-gallate (EGCG)-modified collagen membran...
Source: Biol Sci Space - Category: Science Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
ConclusionCytoreduction and HIPEC can be performed even in children as a feasible and safe treatment with successful outcomes. As for adults, an appropriate multidisciplinary pre-operative work up and a correct cases selection is needed to have the best results even regarding the quality of life.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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