Tumor necrosis factor inhibitors added to nonbiological immunosuppressants vs. nonbiological immunosuppressants alone: a different signal of cancer risk according to the condition. A disproportionality analysis in a nationwide pharmacovigilance database

This study puts the argument of an increased risk of cancer (particularly NMSC) in patients with rheumatoid arthritis exposed to TNFi and NBIS compared with NBIS alone, but not in IBD and ankylosing spondylitis patients. No signal was detected for melanoma potentially related to the lack of power. The signal seems similar whatever the TNFi.

Source: Fundamental and Clinical Pharmacology - December 23, 2015 Category: Drugs & Pharmacology Authors: Layla Saliba, Guillaume Moulis, Malak Abou Taam, Vanessa Rousseau, Leila Chebane, Nadine Petitpain, Bernadette Baldin, Grégory Pugnet, Jean‐Louis Montastruc, Haleh Bagheri Tags: Original Article Source Type: research