Abstract SY34-01: Infection causing cancer: An update on the global burden

Authors: Catherine de Martel1, Jérôme Vignat1, Delphine Maucort-Boulch2,3,4, Eric Engels5, Meredith Shiels5, Edgar Simard6, H Irene Hall7, Silvia Franceschi1, Martyn Plummer11IARC, Lyon, France, 2Department of Biostatistics, Hospices Civils de Lyon, Lyon, France 3CNRS, Laboratoire Biostatistique Sante, UMR 5558, Pierre Benite, France 4Faculte de Medecine Lyon-Sud, Universite Claude Bernard Lyon 1, Villeurbanne, France 5 National Cancer Institute, Rockville, MD, USA 6 American Cancer Society, Atlanta, GA, USA 7Centers for Disease Control and Prevention, Atlanta, GA, USA Eleven infectious agents have been classified as carcinogenic to humans (1): hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus type 1 (HIV-1), Opistorchis viverrini, Chlonorchis sinensis, Human papillomavirus (HPV), Epstein-Barr virus (EBV), Kaposi Sarcoma herpes virus (KSHV), Helicobacter pylori, human T-cell lymphotropic virus type 1, and Schistosoma haematobium.We estimated the global burden of cancer attributable to these infections in the year 2008 (2). Of the 12.7 million new cancer cases that occurred in 2008, 2 million (16.1%) were attributable to infectious agents. The attributable fraction was higher in less developed countries (22.9%) than in more developed countries (7.4%). Four agents - H. pylori, HBV, HCV, and HPV - were responsible for 1.9 million cases worldwide, mainly cancers of the stomach, liver, and cervix.The general methods developed by our group to provide ...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Epidemiology Source Type: research